ID A0A3B3VUE7_9TELE Unreviewed; 775 AA.
AC A0A3B3VUE7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Cadherin-6 {ECO:0000256|ARBA:ARBA00041042};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000028492.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000028492.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They
CC preferentially interact with themselves in a homophilic manner in
CC connecting cells; cadherins may thus contribute to the sorting of
CC heterogeneous cell types. {ECO:0000256|ARBA:ARBA00037319}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
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DR AlphaFoldDB; A0A3B3VUE7; -.
DR STRING; 48699.ENSPLAP00000028492; -.
DR Ensembl; ENSPLAT00000022535.1; ENSPLAP00000028492.1; ENSPLAG00000017933.1.
DR GeneTree; ENSGT00940000154187; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF322; CADHERIN-6; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..775
FT /note="Cadherin-6"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017207054"
FT TRANSMEM 600..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..153
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 154..262
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 259..371
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 372..476
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 476..589
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 775 AA; 86182 MW; B7F0D12023FDB309 CRC64;
MIGNQALLLL MLYFLWPSTA LPFITGNIGN LFGMPESDGK VLQRSKRGWM WNQFFLLEEY
TGNDHQYVGK LHSNADKGDG TVKYVLTGDG AGTLFLIDEK SGDIHATKRL DREEKAMYTL
HAKVLDRNTN AELEPDTEFN IKIHDINDNA PRFDKEVYYA SVPEMSEVGT SVVTVTATDA
DDQTYGNSAK LVYSILQGQP YFSVDSENGT IKTALPGMDR EVKEHYQVVI QAKDMAGQMG
GLSGTTTVSI SLSDVNDSPP RFANLTTVES TEIGGAIGRI KADDPDVGQS AEMEYSIVGG
HDTFNIITDQ ATQEGVIIIK KALDYESKRD YEFRVEVKNT YLDARFIHGV QFKDYATVKV
TVEDVDEPPV FARNPYIIEV HEDTAAGSFV GVVLARDPDA DNKPVKYSID RHTDLERLFN
IDSVNGTITT LKSLDREMSK WHNISVVATE INNPRQTTRV PVFIKVLDVN DNAPEFAMSY
DTFVCENVKA GQLIQTISAV DTDEPLVGHK FVFSISATNP NFTIVDKEDN TANILTRRGG
FSRREMSMYF LPVVISDNDY PIQSSTSTLV VRVCACDSRG NMQSCSPEVL PFSDGLTTGA
LVAILLCVII LLMIVVLFAA LRRQRKKEPL IISKEDVRDN VVSYNDEGGG EEDTQAFDIG
TLRNPEVMDA NKLRRDIIPE MLFPFRRTSP IKDNTDVRDF INGRLQENDA DPTAPPYDSL
ATYAYEGTGS LAESLSSLES AATEGDHDYD YLSNWGPQFK KLAEMYIGRS PDRET
//
