ID A0A3B3VUN3_9TELE Unreviewed; 1146 AA.
AC A0A3B3VUN3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Zinc finger E-box binding homeobox 2 {ECO:0000313|Ensembl:ENSPLAP00000028577.1};
OS Poecilia latipinna (sailfin molly).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000028577.1, ECO:0000313|Proteomes:UP000261500};
RN [1] {ECO:0000313|Ensembl:ENSPLAP00000028577.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger
CC family. {ECO:0000256|ARBA:ARBA00009867}.
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DR RefSeq; XP_014914141.1; XM_015058655.1.
DR AlphaFoldDB; A0A3B3VUN3; -.
DR STRING; 48699.ENSPLAP00000028577; -.
DR Ensembl; ENSPLAT00000030297.1; ENSPLAP00000028577.1; ENSPLAG00000018082.1.
DR GeneID; 106963632; -.
DR CTD; 100003889; -.
DR GeneTree; ENSGT00950000183208; -.
DR OrthoDB; 4266655at2759; -.
DR Proteomes; UP000261500; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:UniProt.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR008598; Di19_Zn-bd.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24391; HISTONE H4 TRANSCRIPTION FACTOR-RELATED; 1.
DR PANTHER; PTHR24391:SF11; ZINC FINGER E-BOX-BINDING HOMEOBOX 2; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR Pfam; PF05605; zf-Di19; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 197..225
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 227..249
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 268..295
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 609..669
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 959..986
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 987..1015
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DNA_BIND 611..670
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1053..1146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..770
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1091..1118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1146 AA; 126730 MW; 4BABB4E90EA7F8B7 CRC64;
MMAQSPRWKR RKQLNPRRKS VLNYDSVLET TSETDEDDQT LLRDDSSFTG GAGDDEEAGS
PVGVPALEAS PRVGHALLSN REPDDSEHRG EDECIDDRSS EYDAVGPEAS LQAVEDGPGR
RLDGISGLDE FFLKRKLEDD DGHHTTIAEY LQRSDTAIIY PEAPEEVTRL STPEAGGQDE
SEHDLPSSAT DDFAQLLTCP YCERGYKRLT SLKEHIKYRH ENTEETFTCL LCAETFNQRA
QLERHMITHK PTVDQPPLLS EGAANRKFKC SECGKAFKYK HHLKEHLRIH SGEKPYECSN
CKKRFSHSGS YSSHISSKKC IGLVALNGRV RNGNNSKPGS SPNSTTSSPG SPALAHLRQK
LENGRLLGLQ DQQGQVDIKT EPMDFNDYRL LMASQHGFGG PGVYLNGHSG SPLANHGSSQ
SSFQQLGGMG IDLSLLGYAG PLGSSLSEVQ KVLQIVDNTV CRQKIDGNPE ELSKLRAYMK
ELGAQMEAQA SFQVIGSNSP TKSIIDYTLE KVNEAKNLIN DSKMQVDVKK EKPNQSVDLS
GEEKFSDGQN QFLTFSCQYC KEIFPGPIPL HQHERYMCKM NEDIKPVLQH LEGSPVGCRG
LRADELSRTE RPHSPTNVFK DHMSVLKAYF AMNADPNSEE LLKISLAVGL PQELVKDWFS
QWKIQNNHMD SLRKKFQTPE RGGPDRSLSR SPVSLPVIDL HNGFINTDPT HRLTKINQFT
ANRQTKGDKP IDPADPLRSN TSSPLNLSST SSKHSQSSSY TPNSLTSEDA HGDTPLDLSL
PKHMAQKRPK PNGFITEHNG EVSVREQGSG SLGLAKIKKE FLGSDSGGSS IHQLEKSTSP
IFGINPFAGG PVYTSLPPHG AFPPPTFISP AQATIPGLRP YAGLDPMSFL PHMAYTYATG
AATFAEMQQR RKYQRKAGFQ GELLDGTADY LSGLDDLTDS DSLLSRKKIK KTESGKRPHQ
CQICKKAFKH KHHLIEHSRL HSGEKPYQCD KCGKRFSHSG SYSQHMNHRY SYCKREAEER
EAAEREAKVG GLAGGLEPTE LLMRRAYLQG LGPLGYSDPE EQPEDGGGTI LRDGREGGGQ
EVGGVDNKMY EEVTDGQEAS FRNREEEGDS RSQMDSMMDE GGKDSAQLMD TCSREGKTDG
TLEQED
//