ID   A0A3B3VW89_9TELE        Unreviewed;       661 AA.
AC   A0A3B3VW89;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Protein numb homolog {ECO:0000256|PIRNR:PIRNR017607};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000030040.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000030040.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Plays a role in the process of neurogenesis.
CC       {ECO:0000256|PIRNR:PIRNR017607}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR017607};
CC       Peripheral membrane protein {ECO:0000256|PIRNR:PIRNR017607};
CC       Cytoplasmic side {ECO:0000256|PIRNR:PIRNR017607}.
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DR   RefSeq; XP_014895272.1; XM_015039786.1.
DR   RefSeq; XP_014895273.1; XM_015039787.1.
DR   RefSeq; XP_014895274.1; XM_015039788.1.
DR   AlphaFoldDB; A0A3B3VW89; -.
DR   STRING; 48699.ENSPLAP00000030040; -.
DR   Ensembl; ENSPLAT00000025580.1; ENSPLAP00000030040.1; ENSPLAG00000020788.1.
DR   GeneID; 106951980; -.
DR   KEGG; plai:106951980; -.
DR   CTD; 8650; -.
DR   GeneTree; ENSGT00940000156005; -.
DR   OrthoDB; 2913102at2759; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0050769; P:positive regulation of neurogenesis; IEA:UniProtKB-UniRule.
DR   CDD; cd01268; PTB_Numb; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR016698; Numb/numb-like.
DR   InterPro; IPR010449; Numb_domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   PANTHER; PTHR47368; NUMB; 1.
DR   PANTHER; PTHR47368:SF5; PROTEIN NUMB HOMOLOG; 1.
DR   Pfam; PF06311; NumbF; 1.
DR   Pfam; PF00640; PID; 1.
DR   PIRSF; PIRSF017607; Numb/numb-like; 1.
DR   SMART; SM00462; PTB; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01179; PID; 1.
PE   4: Predicted;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW   ECO:0000256|PIRNR:PIRNR017607}; Membrane {ECO:0000256|PIRNR:PIRNR017607};
KW   Neurogenesis {ECO:0000256|PIRNR:PIRNR017607};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          37..173
FT                   /note="PID"
FT                   /evidence="ECO:0000259|PROSITE:PS01179"
FT   REGION          225..256
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          339..364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          391..410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          602..623
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        225..255
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        347..361
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   661 AA;  71275 MW;  DCD2988D1942072A CRC64;
     MNKLRQSFRR KKDIYVPESS RPHQWQTDEE AVRSGRCSFA VKYLGHVEVE ESRGMHICED
     AVKRLKTDRK FFKGFFVKAG KKAVRAVLWV SADGLRVVDD KTKDLILDQT IEKVSFCAPD
     RNFERAFSYI CRDGTTRRWI CHCFMAIKDS GERLSHAVGC AFAACLERKQ KREKECGVTA
     TFDANRTTFT REGSFRVTTA TEAAEREEVM RQLQDAKKAE TELNVVGNSA NNVTNSSVLQ
     SGSSPSPSSS PPLSVAALGP QVIPRRHAPA EALARQGSFR GFPALSQKTS PFKRQLSLRM
     NELPSTMQRK SDFPIKNTVP EVEGENDSIS SLCTQIATAF SGPPEDPFSS APMPKPTSSP
     QSPVAPVNGT MPAFSIAATA APAASNPAVL HPALPTRETN PWAANPAGPT APALPGGDWT
     SATPAIVAPP TASPAMSAHK RTPSEADRWL EEVTKSVRVP QSKPMAAGGT PPPQPFAAPV
     HIPMAPVPVV PTVPFMPSLT PPVPMVPPRQ PAFQPPAPAS YPVSNGLPFP QPSVPVFGIT
     PSQMVANVFG SATQPQPFLI PAVATMPQTG DAQAINNVSP YIKAPAPTEV HIQPPNGRAA
     FNGADGWAAS SSQYGQPAPA QQEDAFEAQW AALENRPHQR TTPSPTNPFS TELHKTFEIQ
     L
//