ID   A0A3B3W332_9TELE        Unreviewed;       600 AA.
AC   A0A3B3W332;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Solute carrier family 12 member 3-like {ECO:0000313|Ensembl:ENSPLAP00000031444.1};
OS   Poecilia latipinna (sailfin molly).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48699 {ECO:0000313|Ensembl:ENSPLAP00000031444.1, ECO:0000313|Proteomes:UP000261500};
RN   [1] {ECO:0000313|Ensembl:ENSPLAP00000031444.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC       {ECO:0000256|ARBA:ARBA00010593}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3B3W332; -.
DR   Ensembl; ENSPLAT00000028299.1; ENSPLAP00000031444.1; ENSPLAG00000023671.1.
DR   GeneTree; ENSGT00940000155044; -.
DR   Proteomes; UP000261500; Unplaced.
DR   GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR   GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR013612; AA_permease_N.
DR   InterPro; IPR002948; SLC12A3.
DR   InterPro; IPR004842; SLC12A_fam.
DR   PANTHER; PTHR11827:SF97; SLC12A10.3 SOLUTE CARRIER FAMILY 12 (SODIUM_POTASSIUM_CHLORIDE TRANSPORTERS), MEMBER 10, TANDEM DUPLICATE 3 ISOFORM X1-RELATED; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 1.
DR   Pfam; PF08403; AA_permease_N; 1.
DR   PRINTS; PR01230; NACLTRNSPORT.
PE   3: Inferred from homology;
KW   Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT   TRANSMEM        84..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        106..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        153..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        200..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        226..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        282..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        316..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        391..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        446..463
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        524..543
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          44..80
FT                   /note="Amino acid permease N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08403"
FT   DOMAIN          82..583
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
SQ   SEQUENCE   600 AA;  66204 MW;  3D7DED8222A4D67B CRC64;
     CLQQAAKWSW KVSNKSHSFQ TCFCVLLCSS SERRGSRAEL RRSSVYSTMD LVPQLEHYAN
     TLPRQMTKSR PTLETLRKTF EMRCMLNIWG VIMFLRLSWI TSQAGIVLTC VIILMSVVVT
     SVTALSISAI ATNGRVRSGG AYFMISRTLG PEIGGPIGLV FALANAMACA LHTVGCSLVV
     RDLMHEFGAV MVDPINDVRI IGVITVTVLL MITQAGMEWE SKTQILFFLA LMVSFANYLV
     GTVIPPTVDK QAIGIFGYRG KEFFSFPPNT LFDDWRGAQN DFFRMFAIFF PAATGIMSGV
     NICGDLKDPA TAIPKGTLMA IFWTTLSYLV IAVTTGSCVV RDASGNKSHI LTGNNTDGCV
     GLACNLGWNF TDCSQSQTCR YGLVLGQLSG FYYIIIVGIF AATLSSALGF LVSAPKIFQC
     LCNDQIYPYI IFFAKGYGKN NEPRRAYILC YLIATAVILI ADLNAIAPLI SNFFLCSYAL
     INFSCFHASI TNSPGWRPSF HYYSKWAALF GAIISVVLMF LFTWWAALVT LSIIIFLLGY
     VNYNKPKLNW GSSMQASTYN MALSSSVSLT GVEDHKTNTF NEKMVKWPNK VHTLLNPLTA
//