ID A0A3B3WDT3_9TELE Unreviewed; 1024 AA.
AC A0A3B3WDT3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=CD109 molecule {ECO:0008006|Google:ProtNLM};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000000938.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000000938.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3WDT3; -.
DR Ensembl; ENSPMET00000015049.1; ENSPMEP00000000938.1; ENSPMEG00000001950.1.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF162; CD109 ANTIGEN; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 4: Predicted;
FT DOMAIN 171..302
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 353..441
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 947..1014
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 1024 AA; 113975 MW; 8E8FAA5515B8C22C CRC64;
LTYNLRTVSL FTQTDRSSYK PGDTVNVRVV TFQLDNKPYK GRVDISLGKP VESWNSTGNL
GIVLKEFSLP LMSRPGRWMI TATVNVRLKE RNELPFVLPH VVVKNFSQKK KYIYIVFFHF
DRGDKLQALY SCLSASNTHI LHIAVQFKSG SAGIFHFKQR LQYLNALPQH FDSAAVAPGL
TVNKTLEVHV LRNKFQLMFL NFPSTLKPSL NFSANISSKG QVVAAGTKNF SSSVTLTPEL
SWYPEACVTV YCIHSDGEIT SDTAYISIHQ YNHVTLNWSS ERAQPGEQVS LTVAGSEPRF
QVGITVTAMQ NDALPSDLDY GVGQVGEEHF GLKKTTTFVC SQTYVALKRW SKTSFYLVVS
FSDKNWTSGK ITVPNGVTCL GAVAVSVSDN LGLVLQYKPL TISNDFSLSL AVPSHLIKGE
EIVLEVNVVN HLEQETEFVL MDRRGASIIN AQKITLGGHE SASALFPIRP LVLGEMEISV
DAVSAEASDG LVEKIWVKPE GVEQTFSHTL FLEVMPEKQD SSRSVTFSFP PNLVPGSQRA
QVALVGDILA LSIENLDSLV QLPTGCGEQN MVHFAPSVFV LQYLEKSSQD DAGIRNKALR
YMMQGYEKQL SFQRDDGSFS AFGQSDSSGS TWLTALVLRY FLQAQPYMQI DQTVLTKATA
WLLKHQDSRG EFTEVGKLIH TEMRGGLDDS PVALTAYVLL EMYADNVSLS LRYLESKVSS
GIVSNYTLCL VAYALALGKS NVQERVITEL TRRADYRDGV MMWTISGGLR SNSQQQHSAQ
IEMASYVLLV QFLRGSFLES IPLMKWLSMQ RSHLGGFGTT QDTVVALQVL SYYAAFSGAN
AINLSVNISS PVSSTASLFH IDSTNYRVYQ SREINADEDL PLNIYLEGMG FAIFQVKFVI
LKDSTQDIEP TTDKDAFILN FDLTYNDSNH IMLSMLLEFL YFFFSHTGMA IMEVGMLSGF
SLFSGVAVQV DFIRRVDIGP ERVSLYLDSV NIYIIFIVHQ TRIAHSNVIS MTNFVWVSIL
DLLR
//
