ID A0A3B3WDX8_9TELE Unreviewed; 2683 AA.
AC A0A3B3WDX8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Tower domain-containing protein {ECO:0000259|SMART:SM01341};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000000892.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000000892.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 48701.ENSPMEP00000000892; -.
DR Ensembl; ENSPMET00000015118.1; ENSPMEP00000000892.1; ENSPMEG00000001742.1.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR CDD; cd04493; BRCA2DBD_OB1; 1.
DR CDD; cd04494; BRCA2DBD_OB2; 1.
DR CDD; cd04495; BRCA2DBD_OB3; 1.
DR Gene3D; 6.10.70.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 3.
DR InterPro; IPR015525; BRCA2.
DR InterPro; IPR015252; BRCA2_hlx.
DR InterPro; IPR036315; BRCA2_hlx_sf.
DR InterPro; IPR015187; BRCA2_OB_1.
DR InterPro; IPR048262; BRCA2_OB_2_dom.
DR InterPro; IPR015188; BRCA2_OB_3.
DR InterPro; IPR002093; BRCA2_repeat.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR015205; Tower_dom.
DR PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR Pfam; PF09169; BRCA-2_helical; 1.
DR Pfam; PF09103; BRCA-2_OB1; 1.
DR Pfam; PF09104; BRCA-2_OB3; 1.
DR Pfam; PF00634; BRCA2; 4.
DR Pfam; PF21318; BRCA2DBD_OB2; 1.
DR Pfam; PF09121; Tower; 1.
DR PIRSF; PIRSF002397; BRCA2; 11.
DR SMART; SM01341; Tower; 1.
DR SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR SUPFAM; SSF81878; BRCA2 tower domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR PROSITE; PS50138; BRCA2_REPEAT; 11.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 2184..2225
FT /note="Tower"
FT /evidence="ECO:0000259|SMART:SM01341"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 403..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1388..1445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1487..1511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1601..1630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2580..2599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2628..2656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2683 AA; 295821 MW; B23F2D49F6F69EFA CRC64;
MTLPGDTDSV QPTRPTSKIT DSGFTQKKRK FVYTITTTKS QACGQDFELQ TADLSLKISE
SEQENGKSFV NIPDKEECQR TKNQRNIVEE TINCSLGTKL QDIDMSQLCR DFALDFSQMT
DLKTAENTQR NFSPAACLSV MKQAKQNGKP ANFPNDYSCI SKNRRIPTSN QPCSISEVTM
IDSGFQSGVA DVTHMTSSSF GLPLLENVSQ NRPTLSFKTG MHNFPSANGS GKSKFDVEVP
VQRSGTGQAP DHGKEIELHM ASISTEELWD KEETVGQNKC SQPQKTPLSL LPAEASGFKT
ASNKGIHISL ANLEKAKLFL EATEDKKSSL DNSTKSYHGI IYKTNSIRET TTDTSSNANP
PACAGKSFGN VSSQLTASEK ADVTELCTLL EEADSQFEFT QFRSGKKLPN HQDNHNPPHK
EDKDLDPALL ADIDFDDSFS SEGGKQSTVM MNDKVASVLE NRTHGEKAKA INQCTGMSDL
LKRETPLILP GAEDPEAKCL ENNKALIHSE AFRTAGGNVL HVSTKCLNKA KALFGDLERN
LTDQKPSNQN GENAAITEQK CNRDSDTFRI PERKKENWDV GTKIENCFSK LEGVVCSNNN
VGNRNDTKSG KNNGIDTIIC ENGFRKASGK GISISANYMQ EADVFFKDCH VMEHKEGKKS
FSNFKSPQVS ISKKSVTGCT KLENVNTAVV SHHTKGLRLN EVERNTKFTA ALKNEDGKSF
PTSKPFAMLH PSKSTDLSAF EELCTGDGFC TAAGKNISVS SAAMKKAEFL LNQIHAPEEI
NKETNEKEKA SKTKCLGDKI SNVDTGGFQA VDGKKFAISS APLKKATLLR ESEKSEDEMC
ISSQQPSPKI PVIPVTNLWS GGFSAASGKP VILSSVALEK AQTLFSDISL NMDKVAESAP
FKKDKKHQTE PENICSGFTT AGGANDQMSQ EKFDDLVLAK AVQEEEALSA DGVLESNNVM
WESAGSKKED ETPYADQRFR TNTPVEAVKG CFRDTDKQEK HKENLLPQAS CGFKTASGKK
VEVSSEALKK AENLLGDCVG VMDTVNAALP ESKAIDLPVR NDGFRSASGK PVALSSEALQ
KAKSLFSDIG FGAEDPDASQ MIKSGKNQGG SNNTEKMSCG FTTARGEKVD VLQKNLQKAK
VLFKELDDQV LSKAAQEEDA FFAGHDMDIN KEMLENDLKG KVHMQRSRKA CLAKCYTDDE
KRVSISIPEC SRDANKQVEQ RENILLQASC GFQTASGKRV DVSSEARKKA ETLFSEFEEI
QDKTNAMSSQ SKPSALPLRN CGFHSASGKP MAPSTEAVQK AKSLFGDITF STEDSDFSQT
VKAYGKQDSR SKTEKICCGF TTAKGEKVDV LQKNLQRAKF LFKEVDDLDL TKAMQDADHF
FNQEEGWSID SNSEKSSEQT NTAPVNESGS IKGNMSKLRT NTGSICEEPG NGSIKAKQND
SGFQTASGKT VAVSAEALSR AKFLLSENKA DEESTCVFPA SGKRFSHEGL QKAKTSTGGK
SLPSGADSLS DDHIEEKSHF SICNLNTKSS NQISDIMQKN KSSDPKFQSL NLAGCTETQH
KFLAQEALDC TKALLEDEVL VGQSLLTTSE NLQLLDYQQL SEKSAEEDKG RKRRSAEDLT
AQPPSKRRLL EEFDRTANNP RGSGLHPVKS GPNGIMDRGV FRYGVFLHPN ITKPNRDAKS
FVDTRLQNTI QMPHSEQGDG RSAACRMPTF VPPFFKNAKR DALNKPEARD RKKVPAFVPP
FKKQRVVQQE SSPTQQEDNK QHHSLCLETN SKTDAPLTKT TQSCEEVVTL VNTSNTKTIN
QSVLKVGSVS STEMLHVDDK LSGSQDRTEN IGLARDMQDM RIRKKKRQTI RPLPGSLFLT
KTSGVARIPL KAAVNGNIPG RYSSQELYEC GVHKHVPEIT SQNAESFRFN LLQFVKQETL
AEGGGVQLAD GGWLIPSDDW TAGKEEFYRA LCDTCGVDPK LVSEQWVYNH YRWIVWKQAS
MEKSFPGTMG SLCLTPEQVL LQLKYRYDVE VDHSRRPALR KIMERDDTPA KTLVLCICEI
ISKCQLLHAQ SCSDTKMSQS AETKVETPVA VVRLTDGWYA IKAQLDEPLT AMLHKGRLAV
GGKLIIHGAQ LMGSQDGCSP LEAPDTLMLK ICANSTRRAR WDAKMGFHTD PRPFLLPISS
LYSNGGAVGC VDIFILRSYP MQWMERKSDG GVVFRSVRAE EKEARRFNSH KQKAVELLFA
KVQAEFEKEE EGRIKRQRRR QTVGKQDIGN LQEGEDLYEA VGDDPAYLEA HLSEQQLETL
QAYRRSLMEK KQAELQDRYR RALDAEDNEM SCPKRDVTPV WRLCVADSMT QSSCVYQLNL
WRPSSDLQSL LKEGRRFKVY NLVASDGKKR SSVETVQLTG TKKTQFQELQ VSQEWVSSHF
RQRISTDFVD LQNEEFKPLC GEVDLTGLVI SVVDQQGSSP AFYLVDGKKN FVKVRCFSSL
SQAGLEDIVK PRVLLALSNL QLRGQSIHPT PVVYAGDLTV FSTNPKEIHL QESLDQLKNV
VQGQDHFFLT AEEKLAHLIK SDGSCSSSLQ PQTPVAARRQ DSKTNVAFLK PIKSLGSFTP
VSSNLPAATS STEKDPKTLK RKRALDYLSR IPSPPPISPL GSVVSPCVNK TFNPPRRSGP
PSTLKPVQPA APKATDSVVE DEWVNDEELA MIDTQALHVG NLF
//