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Database: UniProt
Entry: A0A3B3WDX8_9TELE
LinkDB: A0A3B3WDX8_9TELE
Original site: A0A3B3WDX8_9TELE 
ID   A0A3B3WDX8_9TELE        Unreviewed;      2683 AA.
AC   A0A3B3WDX8;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Tower domain-containing protein {ECO:0000259|SMART:SM01341};
OS   Poecilia mexicana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000000892.1, ECO:0000313|Proteomes:UP000261480};
RN   [1] {ECO:0000313|Ensembl:ENSPMEP00000000892.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   STRING; 48701.ENSPMEP00000000892; -.
DR   Ensembl; ENSPMET00000015118.1; ENSPMEP00000000892.1; ENSPMEG00000001742.1.
DR   Proteomes; UP000261480; Unplaced.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR   CDD; cd04493; BRCA2DBD_OB1; 1.
DR   CDD; cd04494; BRCA2DBD_OB2; 1.
DR   CDD; cd04495; BRCA2DBD_OB3; 1.
DR   Gene3D; 6.10.70.10; -; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 3.
DR   InterPro; IPR015525; BRCA2.
DR   InterPro; IPR015252; BRCA2_hlx.
DR   InterPro; IPR036315; BRCA2_hlx_sf.
DR   InterPro; IPR015187; BRCA2_OB_1.
DR   InterPro; IPR048262; BRCA2_OB_2_dom.
DR   InterPro; IPR015188; BRCA2_OB_3.
DR   InterPro; IPR002093; BRCA2_repeat.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR015205; Tower_dom.
DR   PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR   PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR   Pfam; PF09169; BRCA-2_helical; 1.
DR   Pfam; PF09103; BRCA-2_OB1; 1.
DR   Pfam; PF09104; BRCA-2_OB3; 1.
DR   Pfam; PF00634; BRCA2; 4.
DR   Pfam; PF21318; BRCA2DBD_OB2; 1.
DR   Pfam; PF09121; Tower; 1.
DR   PIRSF; PIRSF002397; BRCA2; 11.
DR   SMART; SM01341; Tower; 1.
DR   SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR   SUPFAM; SSF81878; BRCA2 tower domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR   PROSITE; PS50138; BRCA2_REPEAT; 11.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          2184..2225
FT                   /note="Tower"
FT                   /evidence="ECO:0000259|SMART:SM01341"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          403..424
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1388..1445
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1487..1511
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1601..1630
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2580..2599
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2628..2656
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        408..424
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2683 AA;  295821 MW;  B23F2D49F6F69EFA CRC64;
     MTLPGDTDSV QPTRPTSKIT DSGFTQKKRK FVYTITTTKS QACGQDFELQ TADLSLKISE
     SEQENGKSFV NIPDKEECQR TKNQRNIVEE TINCSLGTKL QDIDMSQLCR DFALDFSQMT
     DLKTAENTQR NFSPAACLSV MKQAKQNGKP ANFPNDYSCI SKNRRIPTSN QPCSISEVTM
     IDSGFQSGVA DVTHMTSSSF GLPLLENVSQ NRPTLSFKTG MHNFPSANGS GKSKFDVEVP
     VQRSGTGQAP DHGKEIELHM ASISTEELWD KEETVGQNKC SQPQKTPLSL LPAEASGFKT
     ASNKGIHISL ANLEKAKLFL EATEDKKSSL DNSTKSYHGI IYKTNSIRET TTDTSSNANP
     PACAGKSFGN VSSQLTASEK ADVTELCTLL EEADSQFEFT QFRSGKKLPN HQDNHNPPHK
     EDKDLDPALL ADIDFDDSFS SEGGKQSTVM MNDKVASVLE NRTHGEKAKA INQCTGMSDL
     LKRETPLILP GAEDPEAKCL ENNKALIHSE AFRTAGGNVL HVSTKCLNKA KALFGDLERN
     LTDQKPSNQN GENAAITEQK CNRDSDTFRI PERKKENWDV GTKIENCFSK LEGVVCSNNN
     VGNRNDTKSG KNNGIDTIIC ENGFRKASGK GISISANYMQ EADVFFKDCH VMEHKEGKKS
     FSNFKSPQVS ISKKSVTGCT KLENVNTAVV SHHTKGLRLN EVERNTKFTA ALKNEDGKSF
     PTSKPFAMLH PSKSTDLSAF EELCTGDGFC TAAGKNISVS SAAMKKAEFL LNQIHAPEEI
     NKETNEKEKA SKTKCLGDKI SNVDTGGFQA VDGKKFAISS APLKKATLLR ESEKSEDEMC
     ISSQQPSPKI PVIPVTNLWS GGFSAASGKP VILSSVALEK AQTLFSDISL NMDKVAESAP
     FKKDKKHQTE PENICSGFTT AGGANDQMSQ EKFDDLVLAK AVQEEEALSA DGVLESNNVM
     WESAGSKKED ETPYADQRFR TNTPVEAVKG CFRDTDKQEK HKENLLPQAS CGFKTASGKK
     VEVSSEALKK AENLLGDCVG VMDTVNAALP ESKAIDLPVR NDGFRSASGK PVALSSEALQ
     KAKSLFSDIG FGAEDPDASQ MIKSGKNQGG SNNTEKMSCG FTTARGEKVD VLQKNLQKAK
     VLFKELDDQV LSKAAQEEDA FFAGHDMDIN KEMLENDLKG KVHMQRSRKA CLAKCYTDDE
     KRVSISIPEC SRDANKQVEQ RENILLQASC GFQTASGKRV DVSSEARKKA ETLFSEFEEI
     QDKTNAMSSQ SKPSALPLRN CGFHSASGKP MAPSTEAVQK AKSLFGDITF STEDSDFSQT
     VKAYGKQDSR SKTEKICCGF TTAKGEKVDV LQKNLQRAKF LFKEVDDLDL TKAMQDADHF
     FNQEEGWSID SNSEKSSEQT NTAPVNESGS IKGNMSKLRT NTGSICEEPG NGSIKAKQND
     SGFQTASGKT VAVSAEALSR AKFLLSENKA DEESTCVFPA SGKRFSHEGL QKAKTSTGGK
     SLPSGADSLS DDHIEEKSHF SICNLNTKSS NQISDIMQKN KSSDPKFQSL NLAGCTETQH
     KFLAQEALDC TKALLEDEVL VGQSLLTTSE NLQLLDYQQL SEKSAEEDKG RKRRSAEDLT
     AQPPSKRRLL EEFDRTANNP RGSGLHPVKS GPNGIMDRGV FRYGVFLHPN ITKPNRDAKS
     FVDTRLQNTI QMPHSEQGDG RSAACRMPTF VPPFFKNAKR DALNKPEARD RKKVPAFVPP
     FKKQRVVQQE SSPTQQEDNK QHHSLCLETN SKTDAPLTKT TQSCEEVVTL VNTSNTKTIN
     QSVLKVGSVS STEMLHVDDK LSGSQDRTEN IGLARDMQDM RIRKKKRQTI RPLPGSLFLT
     KTSGVARIPL KAAVNGNIPG RYSSQELYEC GVHKHVPEIT SQNAESFRFN LLQFVKQETL
     AEGGGVQLAD GGWLIPSDDW TAGKEEFYRA LCDTCGVDPK LVSEQWVYNH YRWIVWKQAS
     MEKSFPGTMG SLCLTPEQVL LQLKYRYDVE VDHSRRPALR KIMERDDTPA KTLVLCICEI
     ISKCQLLHAQ SCSDTKMSQS AETKVETPVA VVRLTDGWYA IKAQLDEPLT AMLHKGRLAV
     GGKLIIHGAQ LMGSQDGCSP LEAPDTLMLK ICANSTRRAR WDAKMGFHTD PRPFLLPISS
     LYSNGGAVGC VDIFILRSYP MQWMERKSDG GVVFRSVRAE EKEARRFNSH KQKAVELLFA
     KVQAEFEKEE EGRIKRQRRR QTVGKQDIGN LQEGEDLYEA VGDDPAYLEA HLSEQQLETL
     QAYRRSLMEK KQAELQDRYR RALDAEDNEM SCPKRDVTPV WRLCVADSMT QSSCVYQLNL
     WRPSSDLQSL LKEGRRFKVY NLVASDGKKR SSVETVQLTG TKKTQFQELQ VSQEWVSSHF
     RQRISTDFVD LQNEEFKPLC GEVDLTGLVI SVVDQQGSSP AFYLVDGKKN FVKVRCFSSL
     SQAGLEDIVK PRVLLALSNL QLRGQSIHPT PVVYAGDLTV FSTNPKEIHL QESLDQLKNV
     VQGQDHFFLT AEEKLAHLIK SDGSCSSSLQ PQTPVAARRQ DSKTNVAFLK PIKSLGSFTP
     VSSNLPAATS STEKDPKTLK RKRALDYLSR IPSPPPISPL GSVVSPCVNK TFNPPRRSGP
     PSTLKPVQPA APKATDSVVE DEWVNDEELA MIDTQALHVG NLF
//
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