ID A0A3B3WE17_9TELE Unreviewed; 2333 AA.
AC A0A3B3WE17;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Nipped-B protein {ECO:0000256|RuleBase:RU364107};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000001121.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000001121.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364107}.
CC -!- SIMILARITY: Belongs to the SCC2/Nipped-B family.
CC {ECO:0000256|ARBA:ARBA00009252, ECO:0000256|RuleBase:RU364107}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 48701.ENSPMEP00000001121; -.
DR Ensembl; ENSPMET00000014740.1; ENSPMEP00000001121.1; ENSPMEG00000002020.1.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0009790; P:embryo development; IEA:UniProt.
DR GO; GO:0061780; P:mitotic cohesin loading; IEA:InterPro.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026003; Cohesin_HEAT.
DR InterPro; IPR024986; Nipped-B_C.
DR InterPro; IPR033031; Scc2/Nipped-B.
DR PANTHER; PTHR21704:SF18; NIPPED-B-LIKE PROTEIN; 1.
DR PANTHER; PTHR21704; NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED; 1.
DR Pfam; PF12765; Cohesin_HEAT; 1.
DR Pfam; PF12830; Nipped-B_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU364107};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364107};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364107}.
FT DOMAIN 1768..1948
FT /note="Sister chromatid cohesion C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12830"
FT REGION 122..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 553..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1183..1203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1976..2040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2179..2232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1727..1754
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 122..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..264
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..341
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..453
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..474
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 634..668
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..697
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1976..2004
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2013..2033
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2209..2226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2333 AA; 262800 MW; 0661D11ABBC207E6 CRC64;
MNGDMPHVPI TTLAGIASLT DLLNQLPLPS PLPATTTKSL LFNSRIAEEV NRLLGCRDEN
LASQLAHGLN QVSTEHIELK DNLGSDEPEG DAPLLLQTML ARSPGIFREK NVMQQPMVPP
FKITQNSMHS PAQSANFQPA AISPNPSSRF VGPQSGSSSR YIGQQNSPVP SPYTPQSPAP
GYIQQYPHQQ PPSYNQHQQM CKHVACSCAR TWALECGNLI SGSRPPLILQ SPPPYASSPR
EGGHDQKQHL QQRKKTPTVK EEKDMYDIVS SPNKDSTKLT LKLSRTGGAG GLQPPSSPYD
EVELDALAEI ERIEREAASE KCSKEVQDKD KPLKKRKQDS FPLEPGAGGP GAPTGAPGSG
STGGANAGKL TPQEATAAGN GASRPPLMVS IDLQQAGRAD GQLDPCLAAP IPALEAQRWP
EEPASGPAAV EGSDTALRLK PDGRPEVIKN RPGRSSGKQD GSKATSSSTG AKIPDSFPAQ
LLGGHTGALK NFQIPKINRD RENSGSTESQ MWGQPKVKLE RLGLVKDFEK RPKPVVVLKK
LSVDQIQRII RHSKSGKNRF SGKSGKSGMD PEVLRELPPE LLEEIESTMP MYERVKMNKR
KRSTVNEKPK YAEFSSDEDY DRHKRDKDRA WEFEERERRG SGDHRKSGNR EGRRGSGSRY
RDSSEEDSPP PSMSEIARKM KMKEKQKKRK AYEPKLTQEE LMDSSTFKRF LASIDNILEN
LEDVDFTTMD DDEIPQELLL GKHQLNELGS ESAKIKAMGI TSKIPSDKLV KLLNILEKNI
QDGAKLSTLL NHDHDAESEE RLWRDLIMER VTKSADACLT ALNIMTSTHM PKAVYIEDVI
ERVLQYTKFH LQNTLYPQYD PVYRVDPHGG GMLSSKAKRA KCSTHKQRVI VMLYNKVCDI
VSNISELLEI QLLTDTTILQ VSSMGITPFF VENVSELQLC AIKLVTAVFS RYEKHRQLIL
EEIFTSLARL PTSKRSLRNF RLNSSDQDGE PMYIQMVTAL VLQLIQCVVH LPSDKDVFEE
YDKVDQDVLI TNSYETAMRT AQNFLSVFLK KCGSKQGEED YRPLFENFVQ DLLSTVNKPE
WPAAELLLSL LGRLLVHQFS NKQTEMALRV ASLDYLGTVA ARLRKDAVTS RMDQRSIDRT
DETQQLQKAL LDYMEENAET DPSLVFARKF YIAQWFRDAT TEAEKSMRNQ NPKDEDSSDG
PQHAKELETT GEIMQRAEKR KKFLRNIIKT TPSHFTTLKM NSDTVDYEDS CLIVRYLASM
RPFAQSFDIY LTQILRVLGE SAIAVRTKAM KCLSEVVAVD PSILARSDMQ RGVHGRLMDN
STSVREAAVE LLGKFVLSRP QLTEQYYDML IERILDTGIS VRKRVIKILR DICLEQPTFS
KITEMCVKMI RRVNDEEGIK KLVNETFQKL WFTPTPAHDK ETMTRKILNI TDVVAACRDT
GYDWFEQLLQ NLLKSEEDAS YKPAKKACVQ LVDNLVEHIL KYEESLAENK GVNSTRLVAC
ITTLYLFSKI RAQLMVKHAM TMQPYLTTKC NTANDFMVIC NVAKILELVV PLMEHPSETF
LATIEEDLMK LIIKYGMTVV QHCVSCLGAV VNKVTHNYKF VLVFHLHIKI QNINFSLLFY
FILTTLVANK PFLLRSLFTV GALGRHFDFD LEEFKGTNKI IIKEKVLELL LYFTKHEDEV
VKTKAIIGLG FLVIMHPSQM FVPEVKSLYN GILADPSSSI NLKIQVLKNL QTYLQEEDSR
MQEADREWKK LSKQEDLKEM GDISSGMSSS IMQLYLKQVL EAFFHTESSV RHFALNVIAL
TLNQGLIHPV QCVPYLIAMG TDPEPSMRNK ADQQLVEIDK KYTGFIHMKA VAGMKMSYSL
QQAINSSRKS IVRGFRHDET HSALCSHLYT MIRGNRQHRR AFLISLLNLF DDSAKTEVNM
LLFIADNLAC FPYQSQEEPL FIMHHIDITL SVSGSNLLQT FKELLLKEPR RKEKKVKVWK
NTSDGEDEEG KMNCDSSRSD QEENCNSDEN EDNDDEVVHR PKKSRRPIEN SDSSESDFED
LDVEDVEKVM RLLPDNPIGL LDFANAVQGI LLLLVLKQHL KNLYGFSDSK IQKYSPTESA
KVYDKAVNRK NNVNFHPRQT LDFIFNNMSN ASLTEDVKRR IVKQYLDFKV LMEHLDPDEE
DEEGEASASA NIRNKAINAL LGGSGPMSGP SPRNQAGPET DDDDSDIDER TPGSSRRSRR
AGDPSDPGRM SETVEAMDVI ALCCPKYKDR PQIARVTQKT PNGYTIHWMA GSYSGPWAEA
KKRDGRKLVP WVDTIKESDI IYKKIALTSN HKLSNKVVQT LRSLYAAREG GAS
//
