ID A0A3B3WHP3_9TELE Unreviewed; 606 AA.
AC A0A3B3WHP3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=DNA polymerase alpha subunit B {ECO:0000256|ARBA:ARBA00018596, ECO:0000256|PIRNR:PIRNR018300};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000002262.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000002262.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Accessory subunit of the DNA polymerase alpha complex (also
CC known as the alpha DNA polymerase-primase complex) which plays an
CC essential role in the initiation of DNA synthesis.
CC {ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SIMILARITY: Belongs to the DNA polymerase alpha subunit B family.
CC {ECO:0000256|ARBA:ARBA00007299, ECO:0000256|PIRNR:PIRNR018300}.
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DR RefSeq; XP_014863442.1; XM_015007956.1.
DR AlphaFoldDB; A0A3B3WHP3; -.
DR STRING; 48701.ENSPMEP00000002262; -.
DR Ensembl; ENSPMET00000012815.1; ENSPMEP00000002262.1; ENSPMEG00000003291.1.
DR GeneID; 106930418; -.
DR KEGG; pmei:106930418; -.
DR CTD; 23649; -.
DR OrthoDB; 49016at2759; -.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.60.21.60; -; 2.
DR Gene3D; 1.10.8.530; DNA polymerase alpha-primase, subunit B, N-terminal domain; 1.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR043034; DNA_pol_alpha_B_N_sf.
DR InterPro; IPR016722; DNA_pol_alpha_bsu.
DR InterPro; IPR013627; Pol_alpha_B_N.
DR PANTHER; PTHR23061; DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT; 1.
DR PANTHER; PTHR23061:SF12; DNA POLYMERASE ALPHA SUBUNIT B; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
DR Pfam; PF08418; Pol_alpha_B_N; 1.
DR PIRSF; PIRSF018300; DNA_pol_alph_2; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR018300}; Nucleus {ECO:0000256|PIRNR:PIRNR018300};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 24..249
FT /note="DNA polymerase alpha subunit B N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08418"
FT DOMAIN 348..556
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
FT REGION 108..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 606 AA; 67327 MW; 507FE60C9A4CE382 CRC64;
MALVPTDNLK AELQTFGITC EDDSVLDKML ELCICNRLDT DKMMSEWIAY STTKDGLELT
LDNLEHFEHE LRNKKSKSKS SSWKDESYNR TRDIHSLEEL IKAEEEEENL LDSYSTPGKS
SQKRVLSTPE HPQSKRTSAL LTSPGLLLSP ANFSPSVTPS QKYSQRSGKG EVVVSFGAVQ
GARWTGRKDP GAGVQVNLLE QPDESLRSGY KYMFQRLRDV RNVLSEKIEE MGEKLRSRFS
IEEFSAVSLP AQDSITVLGQ ICCDGNGKLN AQSVLLEAGP EHGGQLVPVD LSELKQYSLF
PGQVVLMEGM NTTGRKLVAS KLYEGDPLPF HSTGAKMETN EAAEPLNILV ACGPYTPSDS
LTFDPLIDLI NVIVRDRPDV CLLFGPFVDS KHEQIEKAKV TETFETIFHR CIDSIVDGTR
SVGCHLVFVP AQRDVHHEFI YPQPPFTLPN PSKDQSQAQR VTLVPDPCTL LIDGVTFGLT
SSDILFHMGA EEISCGTSSD RFSRILKHML TQRSFYPLYP PAEEVNMDYE KFQIHGQMLV
TPDILVVPSE LRYFVKDVAG CVCVNPGRLT KGQVGGTYGR LLIQRSAAPE DGKRESPCLT
AQVVKI
//
