ID   A0A3B3WHX4_9TELE        Unreviewed;       840 AA.
AC   A0A3B3WHX4;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
OS   Poecilia mexicana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000002347.1, ECO:0000313|Proteomes:UP000261480};
RN   [1] {ECO:0000313|Ensembl:ENSPMEP00000002347.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3B3WHX4; -.
DR   Ensembl; ENSPMET00000012677.1; ENSPMEP00000002347.1; ENSPMEG00000003650.1.
DR   Proteomes; UP000261480; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR   Gene3D; 3.40.50.2300; -; 4.
DR   Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR   InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR   InterPro; IPR017979; GPCR_3_CS.
DR   InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24061:SF528; C-FAMILY ODORANT RECEPTOR OLFCD2-RELATED; 1.
DR   PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF07562; NCD3G; 1.
DR   PRINTS; PR00248; GPCRMGR.
DR   PRINTS; PR01535; VOMERONASL2R.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170}; Signal {ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..840
FT                   /note="G-protein coupled receptors family 3 profile domain-
FT                   containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017298939"
FT   TRANSMEM        567..591
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        606..626
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        638..662
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        682..701
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        729..750
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        762..782
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        794..818
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          568..832
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
SQ   SEQUENCE   840 AA;  93551 MW;  F7E138BDD483AD5B CRC64;
     MQGWPELGCA LWQLVVLVSF SQTEEPTCVQ IGDPEIAQLS QDGDIVLGGI FYFHSKALDY
     SLLLFYQLTC RPLVNLKSSL NFREFQFAQT MLFAIEEINN STDLLPGVSL GYNIYDTCGS
     IPKTIKVALA LNNENVNTSS NSDTLCTKPV QVQAIVGETS SSPSTAIGTL IGPFHIPLIS
     HFATCACLSD KTKYPSFLRT IPSDYYQSRA LAQLVKHFGW TWVGAVRTND DYGNNGMATF
     TETAEQLGVC LEYSVSFFRT DSTEKIHKVI ETIQASTSKV IVAFVSHLDM DVLIHEMANY
     NLTGYQWVGS ESWISDSQIA VVDKNHILDG AIGVSIPNTH VKFWETLFSC KFKHEKSDEN
     YRECTGQEDL TGVENSFTDM SLMPIFNNVY KGVYAVAHAL HEILGCGKIC NNNVQLDPLT
     VSMYNVWTKE GEEVYFNENG DPAAKYEVIN WQPRENGIVD FITVGVYDAS LPFDEQLKLQ
     NRSILWSQGS NQVPVSMCSE KCPPGTRKVL QKGKPVCCHD CIGCAEGEMS NITDAVTCVR
     CPPESWSNER RDACVKKEAV FLSYNEIMGI LLTTAALFGT CVTAIVTIIF YKNRKTPLVR
     ANNSELSFLL LFSLTLCFLC SLTFIGQPSK WSCMLRHTAF GITFVLCLSC VLGKTMVVLM
     AFKATLPGRN LMKWFGPTQQ RLSVLAFTLV QVIICILWLS ISPPFPSKNL KEFKEKIILE
     CALGSAVGFW SVLGYIGLLA VLCFVFAFLA RKLPDNFNEA KFITFSMLIF CAVWITFIPA
     YVSSPGNFSV AVEIFAILAS TFGLLICIFI PKCYIMLLKP EKNTKKHMMG KGPPKTYIHK
//