ID   A0A3B3WIP1_9TELE        Unreviewed;       687 AA.
AC   A0A3B3WIP1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Rhophilin, Rho GTPase binding protein 2 {ECO:0008006|Google:ProtNLM};
OS   Poecilia mexicana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000002489.1, ECO:0000313|Proteomes:UP000261480};
RN   [1] {ECO:0000313|Ensembl:ENSPMEP00000002489.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the RHPN family.
CC       {ECO:0000256|ARBA:ARBA00010369}.
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DR   RefSeq; XP_014839220.1; XM_014983734.1.
DR   AlphaFoldDB; A0A3B3WIP1; -.
DR   STRING; 48701.ENSPMEP00000002489; -.
DR   Ensembl; ENSPMET00000012435.1; ENSPMEP00000002489.1; ENSPMEG00000003542.1.
DR   GeneID; 106915838; -.
DR   KEGG; pmei:106915838; -.
DR   CTD; 85415; -.
DR   OrthoDB; 24567at2759; -.
DR   Proteomes; UP000261480; Unplaced.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00136; PDZ; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 1.25.40.280; alix/aip1 like domains; 1.
DR   Gene3D; 1.10.287.160; HR1 repeat; 1.
DR   InterPro; IPR004328; BRO1_dom.
DR   InterPro; IPR038499; BRO1_sf.
DR   InterPro; IPR011072; HR1_rho-bd.
DR   InterPro; IPR036274; HR1_rpt_sf.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR047138; RHPN1_2.
DR   PANTHER; PTHR23031; RHOPHILIN; 1.
DR   PANTHER; PTHR23031:SF5; RHOPHILIN-2-RELATED; 1.
DR   Pfam; PF03097; BRO1; 1.
DR   Pfam; PF02185; HR1; 1.
DR   SMART; SM01041; BRO1; 1.
DR   SMART; SM00742; Hr1; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF46585; HR1 repeat; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   PROSITE; PS51180; BRO1; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS51860; REM_1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01207}.
FT   DOMAIN          25..99
FT                   /note="REM-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51860"
FT   DOMAIN          110..501
FT                   /note="BRO1"
FT                   /evidence="ECO:0000259|PROSITE:PS51180"
FT   DOMAIN          515..583
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   687 AA;  77118 MW;  4139CCD96F742803 CRC64;
     MTDTLLPNGI EDSGGDGKHF RKGCNPLSQT GRSKLQKQRA SLNQQIIKQM RMRAGAENLL
     KATNNNKVKE MVVLELSYVN SNLQLLMGQL EGLNSSVDVY QSAEETTNIP LIALGLKETK
     EVDFSAPFKD FILEHYNEDG RTFEEEIADL MDLRQACRTP SRNETGVELL AKYYSHLPLI
     ENRFFSPTRQ TGIFFTWYDS FTGVPVCQQN LSLEKASMVF NMAALYSQIG TRSDRQTIVG
     LQEAISSFQR AAGMLSNLKA TFTHIPSYDM SPAMVSMLIQ LMIAQAQECL FEKIALPGVQ
     NQFTSLIKMA QEAAKVSEIY DQVHQLMVQT PIKDNVPLFW STMSQVKTNH YRAMAHHFLA
     SALLDHELGP NDDEDQQEKT LSQVYDQLPE GCSPLGILKN KDERERIGKA HIRRAISGHE
     EALRNYSLCQ HLEKLEALQE ILKASHLRSL DKYSDYDNEE EFVDYIEAPD IISKTDHKAE
     MELPAATKVK VTDFFQRLGP LSVFSAKQKW TAPRKIQVCA DDRDLGFTLK GEAPVQVVSL
     DPLSRAATDG LKEGDYIVAV GDKDTKWMGV SDMMRLLKDV DEEGIEIQVV SVIDNSPPMP
     TKSATFSGNL PKTYSMICLA HNDEDKSSKT RKVIKKSSFL SWGLKNKMKS ASTLSLPTDD
     HSGALSWNKP IPTFPNSSAY NNDNFLH
//