ID A0A3B3WJ97_9TELE Unreviewed; 412 AA.
AC A0A3B3WJ97;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Class E basic helix-loop-helix protein 40 {ECO:0000256|ARBA:ARBA00040229};
DE AltName: Full=Class B basic helix-loop-helix protein 2 {ECO:0000256|ARBA:ARBA00042387};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000002883.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000002883.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_014861137.1; XM_015005651.1.
DR AlphaFoldDB; A0A3B3WJ97; -.
DR STRING; 48701.ENSPMEP00000002883; -.
DR Ensembl; ENSPMET00000011795.1; ENSPMEP00000002883.1; ENSPMEG00000003933.1.
DR GeneID; 106929002; -.
DR KEGG; pmei:106929002; -.
DR OrthoDB; 2968390at2759; -.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd19749; bHLH-O_DEC1; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR PANTHER; PTHR10985:SF3; CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 40; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 49..104
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 139..172
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 180..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..267
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 412 AA; 45684 MW; 62F18417587CDAEE CRC64;
MERITSAQPP PYVPKHASMD IPDMRRLEYP IYMCKSRRGM KGRDECKETY KLPHRLIEKK
RRDRINECIA QLKDLLPEHL KLTTLGHLEK AVVLELTLKH VKTLSAVLEQ QQQKIVALQK
DLQIGDNVGD GAETSEEMFR SGFHLCAREV LHYLASQETS RDLTPSHVIS HIQKVAAEVL
HNESSPQPNR SSARESDEAK RPVRQPSALP EAPARNCVPV IQRTCHHGTG EQSGSDTDTD
SGYGGEHDKP KAQWSENNER EVEAKPPTSE RIVGVIKQEG DQPRAKRLRV DSEDEMLSFH
PAGAPGSYVN VSPNQPPFCL PFYLIPPSTA AAAAYLPMLE KCWYPGGMPI MYPGLAGPTP
GLSSEPLPSS LLMSPRAGSP VASPVAHRIP MDSPTLHKAL RQVSPLNLET KD
//
