ID A0A3B3WR40_9TELE Unreviewed; 1048 AA.
AC A0A3B3WR40;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=MLLT10 histone lysine methyltransferase DOT1L cofactor {ECO:0008006|Google:ProtNLM};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000005248.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000005248.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_014845795.1; XM_014990309.1.
DR AlphaFoldDB; A0A3B3WR40; -.
DR STRING; 48701.ENSPMEP00000005248; -.
DR Ensembl; ENSPMET00000007825.1; ENSPMEP00000005248.1; ENSPMEG00000006576.1.
DR GeneID; 106919750; -.
DR CTD; 8028; -.
DR OrthoDB; 163389at2759; -.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20901; CC_AF10; 1.
DR CDD; cd15708; ePHD_AF10; 1.
DR CDD; cd15574; PHD_AF10_AF17; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR049773; AF10-like_CC.
DR InterPro; IPR049781; AF10/AF17_PHD.
DR InterPro; IPR049775; AF10_ePHD.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR PANTHER; PTHR13793:SF93; PROTEIN AF-10; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 23..75
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 80..199
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 135..198
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 205..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 668..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1021..1048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 765..799
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 240..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..700
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1048 AA; 106929 MW; 551A23048FFF3B5A CRC64;
MVCGERCLTA DDKLLTSNMK EMIGGCCVCS DERGWAENPL VYCDGHGCNV AVHQACYGIV
QVPTGPWFCR KCESQERAAR VRCELCPHKD GALKRTDNGG WAHVVCALYI PEVEFANVST
MEPIVLQSVP HERYNKTCYI CEEQGRESKA ATGACMTCNK HGCRQAFHVT CAQFAGLLCE
EQGSDADNVK YCGYCKYHHS KLKHKERDRH KPKHKKGSMD MSPSLVLPNI MVPEKAYNST
ASGGGVTSLP TSSQKRLDDN TGRFTNANFQ EVSSALSVGA SKDGLAADTI KAAAEGKNKK
NSGGAHTVGQ RGGRKSLTSS GKPLPSAVVT MATSSTSASA STGPFHQGLL LTSSSKTPAA
PSSSDFLSFT DPSLRPGSGT SFSSPPSFSS CLVKSSSEGG ASEGTTPLFG SLMSATTTSA
AVGGKLYENS HSHAASETTS LSGSAGYKRS QPAGSGLGMG AGVTVGGEEG VKKKKKGNWR
NRFGPCFTTD AKPTEAAPSL TLPTSSSAAN ATSSSSSTAS TASSVSSTLS GRPGLVSSSG
LGVGIGGERG LGVMGVGGGI QKSPSLLRNG GLQSNSGSTT TGSGVFSVAD GSSSGTAAVA
MGGASAELSQ QQQPTPSLAP PSPFTAAAPL NSTTSAHALP GSVFNLAPPH MFGNRLNPNS
SMAALIAQSE ASPADQEVGD GSSGSQGFSI RASPKTTPRS PIGGLQIRYD SSGSLPGPGL
GLLGAGGVGG GETLPPVATS IEQLLERQWN EGQSFLLQQG AQGDVVAMLK SLHQLQEENR
RLEEQIKTLT MKKERLQLLS AQLSVPFTPS TVSSGDMKGS HLGATDSSLP VTAQDTASCG
GHSSSGSTSS LSASPSVSQS PPQPALNGMA ATAALGGVAG LMGALGAGNA LGIGGIVGAL
NGVIQAPAAG PGSPHTTGTA AGVSLPVNSS AARLGLLSEQ QRLLQHQLQQ LLSSQSSADQ
QQQALLLQLI QQQHQDLQQL QSLSSTAQMP SMPLSGAQLP IANLQSQGAI AANPFLALQH
THTDTHSSGP GKPRVAEKAA GITGQEKT
//
