ID   A0A3B3WS40_9TELE        Unreviewed;       583 AA.
AC   A0A3B3WS40;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=HD domain-containing protein {ECO:0000259|PROSITE:PS51831};
OS   Poecilia mexicana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000005484.1, ECO:0000313|Proteomes:UP000261480};
RN   [1] {ECO:0000313|Ensembl:ENSPMEP00000005484.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-
CC         deoxyribonucleoside + H(+) + triphosphate; Xref=Rhea:RHEA:46148,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18036,
CC         ChEBI:CHEBI:18274, ChEBI:CHEBI:61560;
CC         Evidence={ECO:0000256|ARBA:ARBA00001432};
CC   -!- SIMILARITY: Belongs to the SAMHD1 family.
CC       {ECO:0000256|ARBA:ARBA00005776}.
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DR   AlphaFoldDB; A0A3B3WS40; -.
DR   Ensembl; ENSPMET00000007421.1; ENSPMEP00000005484.1; ENSPMEG00000006922.1.
DR   Proteomes; UP000261480; Unplaced.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 3.30.70.2760; -; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   PANTHER; PTHR11373; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE; 1.
DR   PANTHER; PTHR11373:SF4; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1; 1.
DR   Pfam; PF01966; HD; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51831; HD; 1.
PE   3: Inferred from homology;
FT   DOMAIN          116..269
FT                   /note="HD"
FT                   /evidence="ECO:0000259|PROSITE:PS51831"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   583 AA;  66694 MW;  C67EDEE85E63D2D9 CRC64;
     MASRKRPMGP AASSDEEFKT PEKGVSVVRG SPPDSGFMRW GVEETCQYLQ REGLEEWTDK
     FRGSLLLLVF NDPIHGHVEL HPLLIKIIDT PQFQRLRNIK QLGGTYYVFP GASHNRFEHS
     IGVGYLAGRL VQALNEKQPE LLISRRDILC VQIAGLCHDL GHGPFSHMFD GMFIPKARPG
     INWKHEAASL KMFDYLVDDN HLRPVMEEHG LVLPEDLDFI KEQIAGPTES SSGRGEKWPY
     KGRSKDKSFL YEIVANKRNG IDVDKWDYFA RDCYHLGIQN NFDYRRFLKF ARVCEVDGQK
     HICTRDKEVG NLYDMFHTRN CLHRRAYQHK VGNIIETMIT EAFLKADPHI HVEGSQGKIF
     TLSTAIDDMV AYTKLTDNVF EQILNSSSPE LAEAKLILHK IICRKLYKCL GQTQPDKALT
     ENIHSWEADL AQSIPHSGSH DVDLQPEDFV VTVIMMDYGM KEKNPINNVR FYCKDDPTKA
     IKINKNQVSK LLPEHFAEQL VRVYCKKTDE RTLEAAKKHF VQWCMDRNFS KPQDGDVIAP
     ELTPLKPSWC TNNEGEDSDG CSSKETNVHM NGVKKAKTQL NFQ
//