ID   A0A3B3WVP7_9TELE        Unreviewed;      1270 AA.
AC   A0A3B3WVP7;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=UDENN domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Poecilia mexicana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000006850.1, ECO:0000313|Proteomes:UP000261480};
RN   [1] {ECO:0000313|Ensembl:ENSPMEP00000006850.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_014856714.1; XM_015001228.1.
DR   AlphaFoldDB; A0A3B3WVP7; -.
DR   STRING; 48701.ENSPMEP00000006850; -.
DR   Ensembl; ENSPMET00000005107.1; ENSPMEP00000006850.1; ENSPMEG00000008469.1.
DR   GeneID; 106926358; -.
DR   KEGG; pmei:106926358; -.
DR   OrthoDB; 5398783at2759; -.
DR   Proteomes; UP000261480; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   CDD; cd17677; RUN1_DENND5; 1.
DR   Gene3D; 1.20.58.900; -; 3.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR047278; DEN5A/B.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR036392; PLAT/LH2_dom_sf.
DR   InterPro; IPR004012; Run_dom.
DR   InterPro; IPR037213; Run_dom_sf.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   PANTHER; PTHR46070:SF3; DENN DOMAIN-CONTAINING PROTEIN 5B; 1.
DR   PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR   Pfam; PF03455; dDENN; 1.
DR   Pfam; PF02141; DENN; 1.
DR   Pfam; PF02759; RUN; 2.
DR   Pfam; PF03456; uDENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   SMART; SM00593; RUN; 2.
DR   SMART; SM00800; uDENN; 1.
DR   SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR   SUPFAM; SSF140741; RUN domain-like; 2.
DR   PROSITE; PS50211; DENN; 1.
DR   PROSITE; PS50826; RUN; 2.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          34..585
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
FT   DOMAIN          770..930
FT                   /note="RUN"
FT                   /evidence="ECO:0000259|PROSITE:PS50826"
FT   DOMAIN          1114..1265
FT                   /note="RUN"
FT                   /evidence="ECO:0000259|PROSITE:PS50826"
FT   REGION          135..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          673..706
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        680..706
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1270 AA;  141339 MW;  26D7A67E7BC3ACD4 CRC64;
     MNGTAAATGG SASCRFAHYF VVCGVDTQTG LEPDDGAGES FEQSPIRRSF KSKVLVHYPE
     NTDRNPFNKD AVNMLCLPRG LSFRTQVDSL DPQFHSFTVT SDDGTRSYGF VHTFYEEVTS
     PQIITAMQTL YQMHHVEHHS SSSASSPSSS TSSSASTPSA SSMDSLASSL EESDAESLTS
     GVSGCLGCVG SFDAARDTLY VSKALCLITP LPFLQASRQF LAQLHQAVTS QTAPPLPLES
     YVYNILYEVP LPPPGRSLRF HGVQGPIVCQ RPGPGELPLG DYPLGEAFSL LGVDNMVKLL
     VCALLETQVL LYSKDYQRLM MVAEGITTLL FPFQWQHIYL PIISTPLHHL LDAPVPFLMG
     IQHRNGAQRS SLHLPHEANL CFVDIDSHCV EAPEDLPLFP DQTELIQELS EVLLSFGVPP
     RGGVTTTTTT GSASASPRLS SLVLEDLMED RRNGNLGGEE LAALERLQAL ARRCGGGKVS
     EGGKTLGHVF EEEEEELKAA KLNIQLREVF AVRFAAIFGR YEDFIVNSAM DLDSWLNNRD
     GTCSFDKGSF LSVQPAAHLH FLSRFLETSM FSSFVDGKVV SRWVDREPLQ QLFDSRMERE
     RLYDISDEES RNRPYRKCTT LFESAQAIER RLLKTDHTAI HPHLLDMRIG QGRHHPGYFP
     RLQADVLAQA HNTHKYSSRI TASRRTEPRR SAADHSGTDG EPKQKHAFTR KAFRQSKLLD
     PSPQAVSQTH REFVDGLLSE CRLKTKRMLK ERMGKECVEL GQGEANITGL QENTLIHGLC
     DLLERTWGHG LQIKQGKSAI WSHLLHYQAA QEKMEAPADV PGSNSLDQRL SDDGPLLLRG
     SLIQDMRFIQ TMRDDLSEVG QARAWIHLAL EKKMLSQHLK ELLTHQELLR QLYKPHAFLL
     CEEEREQFLY HLLSLNTVDY LCFTRTFTSI SIPYRVVIIP MKKLSIAMAT VNPWVCVSGE
     LGDSGVRQIP KNAQEIFFQS KNLGRLSTLQ LGVQENSGLL AKCLIDCVVV YNEITGHTYR
     FPCGRWLGKG VGDGSLERVL IGQLVSPGAE EDAGRWSGTP PELASPSQSV RTVLGSLGGR
     TRMHSAEVQE DLREAANNLV KHFHKPEQER GNLTVLLCGE GGLVLALEKF LLHGFRSNRL
     FQRNVFVWDF VEKAVVSMET NDQMGDLHGS TLPKSPPCDL LCRYIHAINS SPRNIGKEGK
     FQLFVCLGIR DRLLSQWFPL LAECPLTART YEDGALLRDR AALHSLCRIL QTLNDFSITL
     EAALVKGVDL
//