ID   A0A3B3X0E3_9TELE        Unreviewed;      1078 AA.
AC   A0A3B3X0E3;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Sema domain-containing protein {ECO:0000259|PROSITE:PS51004};
OS   Poecilia mexicana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000008419.1, ECO:0000313|Proteomes:UP000261480};
RN   [1] {ECO:0000313|Ensembl:ENSPMEP00000008419.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR   RefSeq; XP_014838974.1; XM_014983488.1.
DR   AlphaFoldDB; A0A3B3X0E3; -.
DR   STRING; 48701.ENSPMEP00000008419; -.
DR   Ensembl; ENSPMET00000002488.1; ENSPMEP00000008419.1; ENSPMEG00000010238.1.
DR   GeneID; 106915712; -.
DR   KEGG; pmei:106915712; -.
DR   CTD; 9037; -.
DR   OrthoDB; 5399685at2759; -.
DR   Proteomes; UP000261480; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR   GO; GO:0048468; P:cell development; IEA:UniProt.
DR   GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR   Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 6.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR11036; SEMAPHORIN; 1.
DR   PANTHER; PTHR11036:SF78; SEMAPHORIN-5A; 1.
DR   Pfam; PF01403; Sema; 1.
DR   Pfam; PF00090; TSP_1; 5.
DR   PRINTS; PR01705; TSP1REPEAT.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SMART; SM00209; TSP1; 6.
DR   SUPFAM; SSF103575; Plexin repeat; 1.
DR   SUPFAM; SSF101912; Sema domain; 1.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 6.
DR   PROSITE; PS51004; SEMA; 1.
DR   PROSITE; PS50092; TSP1; 6.
PE   4: Predicted;
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..1078
FT                   /note="Sema domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017304343"
FT   TRANSMEM        972..994
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          43..492
FT                   /note="Sema"
FT                   /evidence="ECO:0000259|PROSITE:PS51004"
SQ   SEQUENCE   1078 AA;  120817 MW;  2A9F1BE3FC5168D8 CRC64;
     MGRPVIQHAL LLLQCMLVLR PCGVASRRGP VLLPESPCHK TEHPLIPHSE MEPWIFRFKA
     EGTVDYSQLT FDPGQNELIV GARNHLFRLN LEDLTLIQEA EWHCDEFTKG ACFSRGKSEE
     ECQNYIRVLL VNGNRLFTCG TNAFTPICTN RTLTNLTEIH DQISGMARCP YNPLHNSTAL
     ITSSGELYAA TAMDFSGRDP AIYRSLGGLP PLRTAQYNSK WLNEPNFVSS YDIGNFTYFF
     FRENAVEHDC GRTVFSRAGR VCKNDIGGRF LLEDTWTTFM KARLNCSRPG EIPFNYNELQ
     GTFYLPELEL LYGIFTTNVN SIAASAVCAF NLSAISQVFN GPFKYQENSR SAWLPYPNPN
     PNFQCGTINS GSYVNLTQRN LQDAQKFLLM HEVVQPVVPV PYFMEDNVRF THIAVDVVQG
     KDTLFHIIYL ATDYGTIRKV LSPLNQSTGS CLLEEIELFP PRKRQPIRSL LILHSRSELY
     VGFRDQVIKI PLKRCSYHKS REACVGARDP YCGWDLLLKK CTTLEESVRM SQWEQSITKC
     PVRNVTVDGG FGAWSGWSTC THNDGGSSGA CLCRTRACDN PAPQCGGQKC YGISVEVANC
     SRNGAWTPWT SWSPCSTSCG IGFQVRQRSC SNPTPRHGGR VCVGQNREER YCNEHLPCPP
     HVYWSAWSAW ERCNVPCGGG IQSRRRTCEN GNDCPGCGQE YQSCNTLPCP DLKKTTPWTP
     WTPVNISDNG GHYEQRFRYT CKARIPDPSL LEVGRQRIEM RYCSSDGSTG CSTDGEVLRL
     GRISGHTVNG GWSSWSSWSQ CSRDCSRGIR SRKRTCSSPE PRYGGQTCLG PAQEFQECNI
     TPCPVDGSWS CWSSWSKCSV TCGGGHYMRT RTCSNPPPAY GGDICLGLHT EEALCNTQTC
     PESWSSWSEW SHCDSGGAQL RVRHCDVLFP TGNQCSGNSS ETRPCSPDSN FIPEVSIARS
     SQEERRCGDF NLFHMIAVGL SSSILGCLVT LLVYSYCQRY QQQSHDATVI HPISAAPLNT
     SITNHINKLD KYDTVEAIKG FNKNNLILEE RNKYFNPQLA GKTYTNAYFS DLNTYDDY
//