ID   A0A3B3X0W9_9TELE        Unreviewed;       292 AA.
AC   A0A3B3X0W9;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=Deoxyribonuclease {ECO:0000256|PIRNR:PIRNR000988};
OS   Poecilia mexicana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000008584.1, ECO:0000313|Proteomes:UP000261480};
RN   [1] {ECO:0000313|Ensembl:ENSPMEP00000008584.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DNase I family.
CC       {ECO:0000256|ARBA:ARBA00007359, ECO:0000256|PIRNR:PIRNR000988}.
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DR   AlphaFoldDB; A0A3B3X0W9; -.
DR   Ensembl; ENSPMET00000002201.1; ENSPMEP00000008584.1; ENSPMEG00000000209.1.
DR   Proteomes; UP000261480; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0004536; F:DNA nuclease activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:InterPro.
DR   CDD; cd10282; DNase1; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR016202; DNase_I.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   PANTHER; PTHR11371; DEOXYRIBONUCLEASE; 1.
DR   PANTHER; PTHR11371:SF28; DEOXYRIBONUCLEASE-1-LIKE 1; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   PIRSF; PIRSF000988; DNase_I_euk; 1.
DR   PRINTS; PR00130; DNASEI.
DR   SMART; SM00476; DNaseIc; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR000988-2};
KW   Endonuclease {ECO:0000256|PIRNR:PIRNR000988};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR000988};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PIRNR:PIRNR000988};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..292
FT                   /note="Deoxyribonuclease"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017218530"
FT   DOMAIN          29..243
FT                   /note="Endonuclease/exonuclease/phosphatase"
FT                   /evidence="ECO:0000259|Pfam:PF03372"
FT   DISULFID        196..233
FT                   /note="Essential for enzymatic activity"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000988-2"
SQ   SEQUENCE   292 AA;  33681 MW;  A3DEDF579D6257CE CRC64;
     MRGRSSSVGC LLLLFCSLMI GGAAGLRICS YNIQRFNTTK AADYRVMHTL TKIVSRCDIC
     VLQEVVDPEL KAVKALVASL NRTGHRYDEH RYEYVSSQSL GKSSDDLQQY VFIYRTHLVK
     QLGQHQYEGK AFVRPPFAVH FSCNKTDIKE FVLVPLHSDP DQAVQEIDWL YDVFEEVSTK
     WNNTNVMFLG DFHAGCAYVT RNDKKKIRLF TNSNFSWLIG DREDTTVTDT TSCPYDRIVV
     HGQSFLKAIR PFSGKVFNFG KEFRLRQSKV GGLWLQQKDP EKRLYFLRID LF
//