ID A0A3B3X3Z3_9TELE Unreviewed; 512 AA.
AC A0A3B3X3Z3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Cdc42-interacting protein 4 homolog {ECO:0008006|Google:ProtNLM};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000009771.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000009771.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the FNBP1 family.
CC {ECO:0000256|ARBA:ARBA00009426}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3B3X3Z3; -.
DR Ensembl; ENSPMET00000000227.1; ENSPMEP00000009771.1; ENSPMEG00000011792.1.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07653; F-BAR_CIP4-like; 1.
DR CDD; cd11628; HR1_CIP4_FNBP1L; 1.
DR CDD; cd11911; SH3_CIP4-like; 1.
DR Gene3D; 6.10.140.470; -; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR011072; HR1_rho-bd.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15735:SF17; CDC42-INTERACTING PROTEIN 4; 1.
DR PANTHER; PTHR15735; FCH AND DOUBLE SH3 DOMAINS PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS51860; REM_1; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..264
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 334..411
FT /note="REM-1"
FT /evidence="ECO:0000259|PROSITE:PS51860"
FT DOMAIN 450..511
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT COILED 106..175
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 341..408
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 512 AA; 59011 MW; 01750D75E8245DDE CRC64;
MDWGTELWDQ YDIIEKHTQS GLELVEKYVK FVKERTEIEQ SYAKQLRNLS KKYNQKRSNK
DEPDCRLSSY QSFVDILNEM NDYAGQRELI AENMIMNICI DLTKYLQELK QERKTYLLEA
KKAQQSLEST YKQLDSSKKR FEREWREAER AAQYAEKTDQ DINATKADVE KAKQQAHMRA
RVAEDCKNDY AAQLQKYNKE QSQFYFNDMP LIFNKLQDLD ERRIRKLGHG YILFSDTEKN
VMPIIGKCLE GITKAGTNVN EKNDSMVIIE QNKSGFERPG DLEFEDYSQG INRASSDSSL
GTPKGPMDLL GKNKSKNFWL FKRSKPTVTE DFGHLPPEQR RKRLQQKLEE ISKELQKEAD
QSEALGKMKD VYEKNPQMGD PASLATQISQ TSQNIERLRG ELNKYEVIIH GFPFLLSSPD
GAHSDESTPD PSQAIYAEFD DDFEDEEPVA PIGKCTAMYN FPGASEGTIS MQEGEVLAVV
EEDKGDGWTR VRRHNGDEGY IPTSYVTITL NK
//
