ID A0A3B3X5D5_9TELE Unreviewed; 1022 AA.
AC A0A3B3X5D5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Rap guanine nucleotide exchange factor (GEF) 4 {ECO:0008006|Google:ProtNLM};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000010233.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000010233.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RAPGEF2 family.
CC {ECO:0000256|ARBA:ARBA00010829}.
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DR RefSeq; XP_014864027.1; XM_015008541.1.
DR AlphaFoldDB; A0A3B3X5D5; -.
DR STRING; 48701.ENSPMEP00000010233; -.
DR Ensembl; ENSPMET00000030914.1; ENSPMEP00000010233.1; ENSPMEG00000012283.1.
DR GeneID; 106930772; -.
DR CTD; 559170; -.
DR OrthoDB; 5473909at2759; -.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd04437; DEP_Epac; 1.
DR CDD; cd01765; FERM_F0_F1; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.8.1240; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF175; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR Pfam; PF00027; cNMP_binding; 2.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 62..147
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 230..305
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 370..471
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 510..645
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 679..715
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 783..1020
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 169..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1022 AA; 116759 MW; 1D632F81250420B2 CRC64;
MVAAHTSSHS SESAEWIICL DKRPAERSGE DVDIILARLR NVKALEGFHP RLLQQICLCG
FYECLEKGIT LFRQGDIGTS WYAVLSGSLD VKVSETSSYR DAVTICTLGT GTAFGESILD
NTPRHATIVT REFSELLRIE QKEFRSLWEK FHHCMAGLLA PPYGVMDSNG SDRMPEKENI
SSNSFVSVSK HPNKKSFPES PAKLHTKSPT QVPSEKILRA GKILRHAILS RVPHMIRDRK
YHLKTYRQCC VGTELVDWQM LQCSCVHSRI QAVGMWQVLL EEGVLNHVDG ETVFQDKYLF
YRFLDDEQED ALIPSEEERR ESQEELQDTL LFLSQIGPDA LMRMILRKPP SERTPDDLEI
IYEELLHIKA LSHLSTTVKR ELAGVLIFES HERAGTVLFH QGEEGTSWYI ILKGSVNVVI
YGKGVVCTLY EGDDFGKLAL VNDAPRAASI VLREDDCHFL RVDKEDFNRI LRDVEANTVR
LKEHGQDVLV LEKSLSSSRN SVQGSSAAHH KYNIMSGTPE KILEHLLEMM RSDSQFTESD
SALDDFVLTH CVFIPNSRLC PVLSDHYHAQ ASQDSEMEKL DYTLNNKRRV IRLVMKWAAV
HGEHLQQQDM VFLEEFLVAV SEDAKVLPAL RDQLTELEKI IKSSADDARS SQRKHKVLLQ
HFNMVDEKLQ KRQPIKGDDE ILFKVYCCDH TYTTIRVPVA SSVREVLEAV ADKLGSAEDL
ILVGLSSAGE KVVFKPNDVS IFSTLSINGR LFACQRDQLD VLVPLSEQEG PSLGSLANFE
LMSSKDVAYH MTFYDWELFH CVHELELIYH TFGRQHVKKT TVNLDLFLQR FNEIQFWVIT
EVCLCSQLNK RVQLLKKFIK IAAHCKEYKN LNAFFAVILG LSHPAVSRLS QTWEKLPSKF
KKFYGEFENL MDPSRNHRAY RLTVAKLAPP VIPFMPLMIK DMTFTHEGNK TFIDNLVNFE
KMRMIAKTVK TVRYFRSQTF SPDSPQAGKH HPDVWTYVRQ LSVIDNQRTL TQLSHGLEPR
RS
//
