ID A0A3B3X9C7_9TELE Unreviewed; 767 AA.
AC A0A3B3X9C7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Carboxylesterase type B domain-containing protein {ECO:0000259|Pfam:PF00135};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000011570.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000011570.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC {ECO:0000256|ARBA:ARBA00005964}.
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DR RefSeq; XP_014845341.1; XM_014989855.1.
DR AlphaFoldDB; A0A3B3X9C7; -.
DR Ensembl; ENSPMET00000018734.1; ENSPMEP00000011570.1; ENSPMEG00000000279.1.
DR GeneID; 106919474; -.
DR CTD; 562702; -.
DR OrthoDB; 4386at2759; -.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042043; F:neurexin family protein binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007416; P:synapse assembly; IEA:UniProt.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002018; CarbesteraseB.
DR InterPro; IPR019819; Carboxylesterase_B_CS.
DR InterPro; IPR000460; Nlgn.
DR PANTHER; PTHR43903; NEUROLIGIN; 1.
DR PANTHER; PTHR43903:SF4; NEUROLIGIN-3; 1.
DR Pfam; PF00135; COesterase; 2.
DR PRINTS; PR01090; NEUROLIGIN.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 624..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 47..156
FT /note="Carboxylesterase type B"
FT /evidence="ECO:0000259|Pfam:PF00135"
FT DOMAIN 158..539
FT /note="Carboxylesterase type B"
FT /evidence="ECO:0000259|Pfam:PF00135"
FT REGION 558..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 767 AA; 86565 MW; 6A6281D5BBF8AC2E CRC64;
MWLCLRRNRF PLQNWRGVHS CTNFSVSLWV LSFCWCFAAL RGQNYHPTVN TQYGKLRGVR
VPLPSEILGP VDQYLGVPYA APPVGEKRFM PPEPPSSWSG IKNATHFAPV CPQNIHNAVP
EIMMPIWFTF NLDIVTTYIQ DQHEDCLYLN IYVPTEDGFL STGDQAAKGN YGLLDQIQAL
RWISENIGFF GGDSNRITVF GSGIGASCVS LLTLSHHSEG LFHRAIIQSG SALSSWAVNY
QPVKYTRLLA EKVGCNVLDT SDMVDCLRKK SSRELVEQDI QPARYHVAFG PVIDGDVIPD
DPEILMEQGE FLNYDIMLGV NQGEGLRFVE NVVDSEDGVS GNDFDFSVSD FVDSLYGYPD
GKDTLRETIK FMYTDWADRD NPETRRKTLV ALFTDHQWVE PSVVTADLHA RYGSPTYFYA
FYHHCQSLMK PAWSDAAHGD EVPYVFGIPM IGPTDLFPCN FSKNDVMLSA VVMTYWTNFA
KTGDPNKPVP QDTKFIHTKA NRFEEVAWSK YNPQDQLYLH IGLKPRVRDH YRATKVAFWK
HLVPHLYNLH ELFHYTSTTT KVPPPETTPK SVSTKRPNGK NWPFNTKRPP MSPAYNSEDK
DSWSEDEETG PLVVDNPRDY STELSVTIAV GASLLFLNVL AFAALYYRKD KRRQDSGHGQ
PSPQRQTTAN DIGHHAPEEE IMSLQMNQTH HECEAGNSNE GALRLASLPD YTLTLRRSPD
DIPLMTPNTI TMIPNSLVGM PNLHPYNTFT TGFNSTGLPH SHSTTRV
//
