ID A0A3B3X9E6_9TELE Unreviewed; 737 AA.
AC A0A3B3X9E6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0000259|PROSITE:PS50850};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000011662.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000011662.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000256|ARBA:ARBA00008335}.
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DR RefSeq; XP_014845322.1; XM_014989836.1.
DR AlphaFoldDB; A0A3B3X9E6; -.
DR STRING; 48701.ENSPMEP00000011662; -.
DR Ensembl; ENSPMET00000018881.1; ENSPMEP00000011662.1; ENSPMEG00000013789.1.
DR GeneID; 106919464; -.
DR KEGG; pmei:106919464; -.
DR CTD; 9900; -.
DR OrthoDB; 2615066at2759; -.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR Gene3D; 2.160.20.80; E3 ubiquitin-protein ligase SopA; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR022308; SV2.
DR NCBIfam; TIGR01299; synapt_SV2; 1.
DR PANTHER; PTHR23511; SYNAPTIC VESICLE GLYCOPROTEIN 2; 1.
DR PANTHER; PTHR23511:SF11; SYNAPTIC VESICLE GLYCOPROTEIN 2A; 1.
DR Pfam; PF07690; MFS_1; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 2.
DR SUPFAM; SSF141571; Pentapeptide repeat-like; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 162..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 590..613
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 645..667
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 679..702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 708..726
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 164..732
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 49..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 737 AA; 83283 MW; 6B8F4CA2ACFE174B CRC64;
MDDDGRYRDG RSDFIRGAKD IAKVAKKQVG KKVGRGVDKM ADEYVKRSYK RFEEEDDDDD
YAGVPSNDGG YYRNDSRAND DEGHSDSTEG HDEDDEIYEG EYQGIPRGDS GKTGGMDGMA
VAEAQQFRDL SAFEGEVRKD REELAQQYET ILQECGHGKF QWTLYFVLGL ALMADGVEIF
VVGFVLPSAE KDMCLSEPNK GMLGLIVYLG MMVGAFVWGG LADRIGRRQT LLISLSINSV
FAFFSSFVQG YSSFLFCRLA SGVGIGGSIP IVFSYYSEFL AQEKRGEHLS WLCMFWMIGG
IYASAMAWAI IPHYGWSFQM GSAYQFHSWR VFVLVCAFPS VAAISALSTM PESPRFYLEN
GKHDEAWMIL KQVHDTNMRA KGYPERVFSV TTIKTVKQID ELVNMSDSAA WHEKWRLKLS
SLFHQVWNNF QTVFSPEYRR TTYMMMAVWF SMSFSYYGLT VWFPDMIKYL QKQEYASRTK
VFVKEKVEHV TFNFTLENQV HRQGQYFNDK FMNVKMRSMV FEDSLFEECY FEDITSSNTF
FKNCTFIATL FYNTDLFKYR LINCKLINST FLHNKEGCLL SDVSDENNAY MVYFVSFLGT
LAVLPGNIVS ALLMDKIGRL RMLAGSSVIS CVSCFFLSFG NSESAMIALL CLFGGISIAS
WNSLDVLTVE LYPSHKRTTA FGFLNALCKL AAVLGISIFT SFVGITKAVP ILFASGALAA
GSFLALKLPE TRGQVLQ
//
