ID A0A3B3X9L8_9TELE Unreviewed; 815 AA.
AC A0A3B3X9L8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=MCF.2 cell line derived transforming sequence a {ECO:0008006|Google:ProtNLM};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000011649.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000011649.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B3X9L8; -.
DR Ensembl; ENSPMET00000031481.1; ENSPMEP00000011649.1; ENSPMEG00000013912.1.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR22826:SF146; PROTO-ONCOGENE DBL; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00150; SPEC; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 1..75
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 429..607
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 625..741
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT COILED 216..243
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 815 AA; 93942 MW; C4CECD418D96CD32 CRC64;
MREEASFPGN LHLVLVLRPT SFFHRTVTDI GFRFSQDDFM LKMPVVMLSS VTDLLRYIDE
NQLTSEFGGT LDYCHSDWIV LRTAIESFAV TVKDIAQMLQ GFGTELAEAE LPDEGKAIEQ
LLETHTEKYK KLKDAIRSVS KEGRHLLSNL ETTGKDDDSQ LLAQLRDMES AFDGFFEKHH
LKLHQYLQLL RYEQSFQEME MCLEHLMHQE RELSINVNTL AQTEQLLKRL DDLETNAQEV
MSRAQIIILH GHQLSAGHHY AMGLIMQRCN ELRHHCDTLS AALKSKHSFL MQTHQLLLCL
GQAQTWCDDG AYLLANQLVD KSQSKEGAQM SLREIEKFLE GAPSVLSSVQ QMIQNRQASL
RKLADRHVRP IQLVAPRPEN QPRAKSPLFS PKHVLTFLRS FQIEVIHDYQ ESRSCVSYSL
DGDDSPDLLK RHVMRELIET ERIYVEELLS VLLGYRAEMD NPALSGLLPP ILRSKKDILF
GNMPEIYNFH IFLQDLEGCL EAPETVGACF LHLKESFQMY EMYCQNKPRS EALWRQFSDC
AFFQECQKKL EHKLGLDSYL LKPVQRLTKY QLLLKELLKY SPDCEGTSEL QGALTAMLDL
LKSVNDSMHQ IAITGYEGEI CELGRVLMQG SFSVWISHKR GPTRMKELAR FKPMQRHFFL
YERALLLCKR REDHGDGSDK TPSYSFKHCL KMTAVGITEN VKGDVKKFEI WYSGREEVYV
VQAPTVEVKM AWLNELRRIL TNQQKLLRET IGVFLEALAE RLSPGWPGAH HSVDICEGLE
EWPGDPDAFL PSETEEKKMV KLVREQQQQQ QQKTQ
//
