ID A0A3B3XBA5_9TELE Unreviewed; 680 AA.
AC A0A3B3XBA5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=protein-serine/threonine phosphatase {ECO:0000256|ARBA:ARBA00013081};
DE EC=3.1.3.16 {ECO:0000256|ARBA:ARBA00013081};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000012244.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000012244.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class dual specificity subfamily.
CC {ECO:0000256|ARBA:ARBA00008601}.
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DR RefSeq; XP_014840782.1; XM_014985296.1.
DR RefSeq; XP_014840784.1; XM_014985298.1.
DR RefSeq; XP_014840785.1; XM_014985299.1.
DR AlphaFoldDB; A0A3B3XBA5; -.
DR STRING; 48701.ENSPMEP00000012244; -.
DR Ensembl; ENSPMET00000019618.1; ENSPMEP00000012244.1; ENSPMEG00000014405.1.
DR GeneID; 106916780; -.
DR KEGG; pmei:106916780; -.
DR CTD; 393854; -.
DR OrthoDB; 2901840at2759; -.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0017017; F:MAP kinase tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14645; DSP_DUSP8; 1.
DR CDD; cd01446; DSP_MapKP; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR048035; DUSP8_DSP.
DR InterPro; IPR008343; MKP.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR10159; DUAL SPECIFICITY PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR10159:SF108; DUAL SPECIFICITY PROTEIN PHOSPHATASE 8; 1.
DR Pfam; PF00782; DSPc; 1.
DR Pfam; PF00581; Rhodanese; 1.
DR PRINTS; PR01764; MAPKPHPHTASE.
DR SMART; SM00195; DSPc; 1.
DR SMART; SM00450; RHOD; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912}.
FT DOMAIN 25..140
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT DOMAIN 162..304
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 224..285
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 341..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..577
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..636
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..663
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 680 AA; 73521 MW; 5D317C2058A53407 CRC64;
MAGEKAPNKR SAMDIKRLAS LIQRGTGRLL VIDSRTFSEY NASHVQGAVN VCYSKLVKRR
LQQDKVSVTE LLQPNGKVKV ELGRKQEVVV YDQSSKEAGH LSKDGFVHIL MGKLEGTFHK
VSLLTGGFAA FSSCFPGLCE GKPATALPMS LSQPCLPVAN VGPTRILPHL YLGSQKDVLN
KDLMSQNGIT YVLNASNTCP KPDFISESHF MRIPVNDNYC EKLLPWLDKT NEFIDKAKVS
NCRVIVHCLA GISRSATIAI AYIMKTMGLS SDDAYRFVKD RRPSISPNFN FLGQLLEFEK
GLRLLQALTT DDKKSENNSK QSSEVNGVSA GFEINGHHTS CDSSVADPHA QTEPKLPSPT
SLQQGFNGLH LSAERIMDTN RLKRSFSLDI KSVYSLSSPH CPSMAPTHSE DIPKLCKLDS
PGTGTSNGVC SQSPVLHSPG SFDSPFPSPS SGGSIGGLGG SEGVHRSGTS SSRSRRKTKH
NCGSSPVHSH LQHPPQSLSL SLDHKSPSLE ENLRGSPLLS LPSLPSLGSG AMWTKHRDTV
QATTPVTPVT PTMDAPWHFG ADEGGEGEME LGGGDGRGEE SSVRFGSSSA YVAFGCSEGA
RLRDKSQREK LSGPQTQRDH WDSTSASSSN GVPASEKQFK RRSCQMEFEE GISETRSREE
LGKIGKQSSF SGSMEIIEVS
//
