ID   A0A3B3XBU5_9TELE        Unreviewed;      1252 AA.
AC   A0A3B3XBU5;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
OS   Poecilia mexicana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000012448.1, ECO:0000313|Proteomes:UP000261480};
RN   [1] {ECO:0000313|Ensembl:ENSPMEP00000012448.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3B3XBU5; -.
DR   Ensembl; ENSPMET00000019863.1; ENSPMEP00000012448.1; ENSPMEG00000014768.1.
DR   Proteomes; UP000261480; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR12877:SF14; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10; 1.
DR   Pfam; PF19057; PH_19; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF19056; WD40_2; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}.
FT   DOMAIN          303..490
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          1..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          160..193
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1111..1150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1168..1187
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          194..245
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..17
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1111..1145
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1252 AA;  138710 MW;  ADFEEBFAB8088670 CRC64;
     VPFDDEDEGE PFDFDSGDDI PEAPPAPPSF PSEDPNTEGE SASLNDPHPP QGLPRTSSQS
     KVNPYSVIDI TPIQLQQEHI TSGYSVPVPC GYATPSGVPL ITPAYTTPVI IRHLSVDEDG
     KVEILTRECF KLISSCIFVL HTDPDEMIYD DVELGEEGGC SSSLDNGWSS SEFESYDEAS
     DGEDRPENGL PHLSQDLTRL KEHYEKKMKE LMASTVGAVE LQQLKQKHEQ KMQKLVKAAK
     EGTKDGLEKT KAAVKRGRSF IKTKSKLACF EDESEVFIEV DCFNNVEPVL PPTPQGLSQQ
     QLVRRCILGS ILDSEKNYLD ALKRILEQYE KPLSQIEPRL LSDRKLKIIF YRVREILQCH
     FLFQIALASR VSEWDSLEMI GDVFVASFSK SMVLDAYSEY VNNFSTAMAV VRKTCASKPS
     FLEFLKHRQE SSSDRMTLYG LMMKPIQRFP QFILLLQDML KNTPVGHADR LPLQMALTEL
     ETLAEKLNEK KREADQRCEI RHIAKAMNER YLNKLLSNGS RYLIRSDDMV ETVYNERGEI
     IKTKERRLFL LNDVLMCATP NIRCHDGSGS GSGNAPFDQK FLLKWSVPLN FVEVLEFGSS
     EEMVDNSRYP APHSGEKVVI NAKPNKLYMG PGQLYQDLQN LIHDLGLVNQ IAGMIGSLKG
     NYQNVNSTVA QDWVSGLQRL ILKKEEEIRA ADRCRIQLQL PGKNDKAGKP TYFSAVFNTL
     SPAIKQSWIS NLQMAKLALE EDNLQGWFFA DDDGNHIKKQ KHPLLLRQMP VVMSKLQEFK
     VECAVHNPEP YINTESTADS PVVGHGCVWV ASCTNQMGQI AIVAMQNSCP KVTECFNVES
     RILCMAYVPT EQLKEDGEKL PDSNYAPPAK ASDTPTVCLG MEEGSIIVYK STQRSKKIRL
     QHFFTPDKST VTSLVYKKPC LYAGLVSGAV AIYSRSQDGS WSCEKPKLLK LGVLPVKAVL
     AVEDHLWASS GGQVFIISTH THCVERQLEA HQEEGMVVSH MVVAGVGIWI AFSSGSTVRL
     FHTETLEHLQ DINIATTVNN ILPGNQRVSV SSLLVCHGLL LAGTNLGVTV ALSVPRLQGI
     PKVTGRGMVS LHAHNGPVKF LTMATAVRNW SSSLPSSTPS SSLQQIESVD ADSAQPVSDT
     ASSPPQGRGV WLGEAGCTTM ALQDSLSSSS CGSLAPSQGS LEHGPEDGAL YDLLHDPAHH
     QRGRRSSKMD VSSLLVVSGG LGHRRVNKKT KQSRHEDNTS TIMIWQIPLL NM
//