ID A0A3B3XFA8_9TELE Unreviewed; 1065 AA.
AC A0A3B3XFA8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=SEC24 homolog D, COPII coat complex component {ECO:0008006|Google:ProtNLM};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000013761.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000013761.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
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DR RefSeq; XP_014863800.1; XM_015008314.1.
DR AlphaFoldDB; A0A3B3XFA8; -.
DR STRING; 48701.ENSPMEP00000013761; -.
DR Ensembl; ENSPMET00000021544.1; ENSPMEP00000013761.1; ENSPMEG00000016096.1.
DR GeneID; 106930639; -.
DR KEGG; pmei:106930639; -.
DR CTD; 9871; -.
DR OrthoDB; 977017at2759; -.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR PANTHER; PTHR13803:SF6; PROTEIN TRANSPORT PROTEIN SEC24D; 1.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 2.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 392..430
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 469..712
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 718..802
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 814..913
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 934..1006
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 33..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 128..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..71
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1065 AA; 116088 MW; C1928B9539DC4148 CRC64;
MSQQGYVAAP PYSQAQPGIG GYQGGFGAPP AQPLYGHYGG PPQGFNAPPA GMMKSPPTSP
AAMPPPPVSS QYNPSVQQNG AHPQRYASPS AASPPYGQPS HSVYNSMASP APPTQQLANQ
MSAMNLGSYA PGAMQSHPPP PTSSAAQQHF QTPAPAMGQP QMHSAPAPHM ASQNQMSPPQ
SPLTNMPASG QPMGGQSMTG PPMGGQSMTG PPMGGQSMTG PPMAGMNRPF PGPPPSGQGA
FQQHGTGPTA PSGYPQQSGQ FGGLMSGPQP GMPGAFPGSP GGLAGPPQKK LDPDSIPSTT
QVIEDDKARL GGQVFSTNIR GQVPPLVTTD FTVQDQGNAS PRFIRCTTYS LPCTAELAKQ
CQVPLASIIK PFAKLPKNET PLYVVNHGET GPIRCNRCKA YMCPYMQFID GGRRYQCSFC
NCVNEVPVFY FQHLDHMGRR VDFYERPELS LGSYEFVATL DYCKNNKPPN PPAYIFMIDV
SYTNIKSGLV KLVCDELKTL LEKLPREDGA EASAIKVGFV TYNKVLHFYN VKSALAQPQM
MVVSDTAEMF VPLLDGFLVN YQDSRAVIYN LLDQIPDMFA DTNESETVFA PVIQAGVEAF
KAAECSGKLF IFHSSMPTAE APGKLKNRDD KKLVNTDKEK TLFQPQKGVY EQLSKDCVAQ
GCCVDLFLFP SQYLDLASMA DVPSHTGGSV YKYNNFQVAT DGEHFLRDLR KDLQKSLGFD
AVMRVRTSTG FRATDFFGAI YMNNTTDVEM AAVDCDKAVT VEFKHDDALS EELGAFMQCA
LLYTTISGQR RLRIHNLSLN CTSQLSEMYK CCETDSLINF FAKSAYRAIL NQPVKNVRDI
LVNQTAHMLA CYRKNCASPS AASQLILPDS MKVFPVYMNS LMKTAPLVGS TELSTDDRAH
QRLSVMAIGV EDSQLQLYPR LIPLHDLDAS GEAVPAPVRC SEERLSDSGL FLLENGHSIF
LWLGQASPPD LIQSLFNVPS LAHLQQEHMF TLPELDNPLS KKVRAIISEL LEKRPNSMKL
QIVRQRDKPE MLFRQLLVED KGLHGGASYM DFLCYVHREI RQLLT
//
