ID A0A3B3XFP0_9TELE Unreviewed; 916 AA.
AC A0A3B3XFP0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Calx-beta domain-containing protein {ECO:0000259|SMART:SM00237};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000013785.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000013785.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in);
CC Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033667};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC8 subfamily. {ECO:0000256|ARBA:ARBA00007489}.
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DR AlphaFoldDB; A0A3B3XFP0; -.
DR STRING; 48701.ENSPMEP00000013785; -.
DR Ensembl; ENSPMET00000021578.1; ENSPMEP00000013785.1; ENSPMEG00000016143.1.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 2.60.40.2030; -; 2.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR032452; Na_Ca_Ex_C-exten.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00845; caca; 1.
DR PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR PANTHER; PTHR11878:SF8; SODIUM_CALCIUM EXCHANGER 2; 1.
DR Pfam; PF03160; Calx-beta; 2.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR Pfam; PF16494; Na_Ca_ex_C; 1.
DR PRINTS; PR01259; NACAEXCHNGR.
DR SMART; SM00237; Calx_beta; 2.
DR SUPFAM; SSF141072; CalX-like; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..916
FT /note="Calx-beta domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017336428"
FT TRANSMEM 85..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 173..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 741..765
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 818..838
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 850..870
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 891..910
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 382..482
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 508..607
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
SQ SEQUENCE 916 AA; 101514 MW; 657CBB6448DA9066 CRC64;
MGLLSFHHGA LFFVFFFLLL LCHPCISIRP QVLERASAPE QPESSDNSTE SDKRTCTGVV
VCKPGILLPV WEPLDPPVGE QAGRAIVYFL SLMYIFLGVS IIADRFMASI EVITSQEKEV
TITKPDGETT VKTVRVWNET VSNLTLMALG SSAPEILLSV IEVCGHNFNA GELGPGTIVG
SAAFNMLVII GLCVSVIPDG QSRKIKHLRV FFITAFWSIF AYIWLYLILA VISPGIVEVW
EAVVTLLYFP VCVMLAWIAD RRLLFYKYMH KRYRANKRHG IVVEMEGDDS PKGIDVIMDG
KLSDGIFHLQ PVSSLGQVVR ILKDLKEKHP DKDLDQLIEM ANYSALVHQK KSRAFYRVQA
TRRMIGAGNI LKKHAADQKR RTPGQDADKA TCSHICFESV QYQCTENCGS VTLWVVLDGG
TGQNTFYVDY CTENGSANAG SDYEFNKGTL TFKPGETRKE IKVGILDDEI FEEDEHFFVR
LQNLRLEEGG SEGTGSPPKA RLVEPLLATV TILDDDHAGI FTFGQQVLRV SESTGVLTVT
VLRNSGSRGT VAVPYHTEDG SAKAGVDYEE ARGEVEFTNE QTSQTLQICI LNVEEYEKQE
NFFVVLEDPK WLKRGISGES SSSFTFIRVT CNPTPEEEEA RRISEMGKPI LGEHSRLEVI
IQEACDFKNT VDQLLQDTNL AEVIGTHSWK EQFIEAVTVS AGDDDEEGQD QRTPNCFDYF
MHILCVFWKI LFAFVPPTEY WNGWACFIVS ISVIGLLTAI IGDLASHFGC TVGLRDTVTA
VVFVALGTSL PDTFASKVAA TQDQYADASV GNVTGSNAVN VFLGIGLAWS VAAVYWEVKG
KVFRVDPGSL AFSVTLFTIF AFFSMGVLML RRRPSIGGEL GGPRIPKALT SLLFFGLWFL
YILFSSLEAY CHIQGF
//
