ID   A0A3B3XHB7_9TELE        Unreviewed;       414 AA.
AC   A0A3B3XHB7;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=Acid phosphatase 2, lysosomal {ECO:0008006|Google:ProtNLM};
OS   Poecilia mexicana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000014373.1, ECO:0000313|Proteomes:UP000261480};
RN   [1] {ECO:0000313|Ensembl:ENSPMEP00000014373.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC       {ECO:0000256|ARBA:ARBA00005375}.
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DR   RefSeq; XP_014844223.1; XM_014988737.1.
DR   AlphaFoldDB; A0A3B3XHB7; -.
DR   STRING; 48701.ENSPMEP00000014373; -.
DR   Ensembl; ENSPMET00000022349.1; ENSPMEP00000014373.1; ENSPMEG00000016761.1.
DR   GeneID; 106918746; -.
DR   KEGG; pmei:106918746; -.
DR   OrthoDB; 5489935at2759; -.
DR   Proteomes; UP000261480; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd07061; HP_HAP_like; 1.
DR   Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR   InterPro; IPR033379; Acid_Pase_AS.
DR   InterPro; IPR000560; His_Pase_clade-2.
DR   InterPro; IPR029033; His_PPase_superfam.
DR   PANTHER; PTHR11567; ACID PHOSPHATASE-RELATED; 1.
DR   PANTHER; PTHR11567:SF145; TESTICULAR ACID PHOSPHATASE; 1.
DR   Pfam; PF00328; His_Phos_2; 1.
DR   SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR   PROSITE; PS00616; HIS_ACID_PHOSPHAT_1; 1.
DR   PROSITE; PS00778; HIS_ACID_PHOSPHAT_2; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..414
FT                   /note="Acid phosphatase 2, lysosomal"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017347959"
FT   TRANSMEM        379..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   414 AA;  46923 MW;  CD336E7E751D04C0 CRC64;
     MMWTTLGCFY LLCCICLTES QQLKFVVAVF RHGDRSPIES YPRDPHGEEV WAQGFGQLTE
     LGMKQQFELG GFLRRRYGNF LSEEYNSKEL YVRSTDYDRT LMSAQACLAG MFPPTRRPPP
     IMPQLLWRPI PVHTVPRAQD KLLKSPGKDC PRFRALMTET FESAPYQRFL RTHQSFVERL
     SNHTGYPVSR LVGKKIWRVH DTLTCQRIHN LTLPRWATPD VLETLRRIAS FEVTYSILSH
     KRREKARLSG GVLLNAILRN FSDAMERSSS GGTALKFIIY SAHDSTLITL QAALDVYDGL
     LPPYAACQLF EFYQEDDGSY SVELHYRNES SSEPYPSRVP GCGGLSRCPL TSFTELVRDV
     MPEDWEAECG IKTRWSSTGI ITALAVAVGL LGVALLCSIA VAVHQRTAAY SRDL
//