ID   A0A3B3XHC6_9TELE        Unreviewed;       525 AA.
AC   A0A3B3XHC6;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS   Poecilia mexicana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000014437.1, ECO:0000313|Proteomes:UP000261480};
RN   [1] {ECO:0000313|Ensembl:ENSPMEP00000014437.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   RefSeq; XP_014827128.1; XM_014971642.1.
DR   RefSeq; XP_014827129.1; XM_014971643.1.
DR   STRING; 48701.ENSPMEP00000014437; -.
DR   Ensembl; ENSPMET00000022414.1; ENSPMEP00000014434.1; ENSPMEG00000000680.1.
DR   Ensembl; ENSPMET00000022420.1; ENSPMEP00000014429.1; ENSPMEG00000000680.1.
DR   Ensembl; ENSPMET00000022435.1; ENSPMEP00000014437.1; ENSPMEG00000000680.1.
DR   GeneID; 106906386; -.
DR   KEGG; pmei:106906386; -.
DR   CTD; 325034; -.
DR   OrthoDB; 460351at2759; -.
DR   Proteomes; UP000261480; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd01093; CRIB_PAK_like; 1.
DR   CDD; cd06655; STKc_PAK2; 1.
DR   Gene3D; 3.90.810.10; CRIB domain; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR000095; CRIB_dom.
DR   InterPro; IPR036936; CRIB_dom_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR033923; PAK_BD.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR035064; STK_PAK2.
DR   PANTHER; PTHR48015; SERINE/THREONINE-PROTEIN KINASE TAO; 1.
DR   PANTHER; PTHR48015:SF22; SERINE_THREONINE-PROTEIN KINASE PAK 2; 1.
DR   Pfam; PF00786; PBD; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00285; PBD; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50108; CRIB; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}.
FT   DOMAIN          72..85
FT                   /note="CRIB"
FT                   /evidence="ECO:0000259|PROSITE:PS50108"
FT   DOMAIN          250..501
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          1..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          131..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..76
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         279
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   525 AA;  58044 MW;  3293F5D0B7E45C8B CRC64;
     MCDNGDPEDK PPAPPVRSGS AIFGTGKDSY SANHKPLPSV PEERKQRKGI MSILSGAEKG
     RKKDRDKERP EISPPSDFEH TIHVGFDAVT GEFTGMPEQW ARLLQTSNIT KSEQKKNPQA
     VLDALKFYDS TGNGRQKYLS FPSSEKEAFP AGPQSPVKKS SEPSSPNIKD IDDDDDDETP
     PPIVAPRPEH TKSMYTRSVI DPIPAPSTCP DGDAASKSAD RPKRKTKMTD EEIMDKLRTI
     VSIGDPKKKY TRYEKIGQGA SGTVFTAIDV ATGQEVAIKQ INLQKQPKKE LIINEILVMK
     ELKNPNIVNF LDSFLMGEEL FVVMEYLAGG SLTDVVTETC MDEPQIAAVC RECLQALDFL
     HANQVIHRDI KSDNVLLGMD GSVKLTDFGF CAQITPEQSK RSTMVGTPYW MAPEVVTRKA
     YGPKVDIWSL GIMAIEMVEG EPPYLNENPL RALYLIATNG TPELQNPEKL SPVFRDFLNR
     CLEMDVEKRG GGKELLQHPF LKLAKPLSSL TPLILAAKDA MKGTR
//