ID A0A3B3XHF7_9TELE Unreviewed; 780 AA.
AC A0A3B3XHF7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=General transcription and DNA repair factor IIH helicase subunit XPB {ECO:0000256|ARBA:ARBA00014343};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE AltName: Full=DNA excision repair protein ERCC-3 {ECO:0000256|ARBA:ARBA00032205};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000014424.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000014424.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR RefSeq; XP_014837396.1; XM_014981910.1.
DR STRING; 48701.ENSPMEP00000014406; -.
DR Ensembl; ENSPMET00000022388.1; ENSPMEP00000014406.1; ENSPMEG00000016987.1.
DR Ensembl; ENSPMET00000022397.1; ENSPMEP00000030420.1; ENSPMEG00000016987.1.
DR Ensembl; ENSPMET00000022423.1; ENSPMEP00000014432.1; ENSPMEG00000016987.1.
DR Ensembl; ENSPMET00000022433.1; ENSPMEP00000014444.1; ENSPMEG00000016987.1.
DR Ensembl; ENSPMET00000022451.1; ENSPMEP00000014452.1; ENSPMEG00000016987.1.
DR Ensembl; ENSPMET00000022592.1; ENSPMEP00000014424.1; ENSPMEG00000016987.1.
DR Ensembl; ENSPMET00000032603.1; ENSPMEP00000030436.1; ENSPMEG00000016987.1.
DR Ensembl; ENSPMET00000032606.1; ENSPMEP00000030440.1; ENSPMEG00000016987.1.
DR GeneID; 106914831; -.
DR KEGG; pmei:106914831; -.
DR CTD; 2071; -.
DR OrthoDB; 1360679at2759; -.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd18029; DEXHc_XPB; 1.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001161; XPB/Ssl2.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR NCBIfam; TIGR00603; rad25; 1.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 324..485
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 539..699
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 761..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 780 AA; 88933 MW; 4C6B40184ED9EE26 CRC64;
MGKRDKEKKS KKRYYEEEDD EDDVTGSEPQ EAVPAAAGKQ VDESGTKLDE YGAKDYRSQM
QLKKDHSSRP LWVAPDGHIF LEAFSPVYKY AQDFLVAIAE PVCRPNHVHE YKLTAYSLYA
AVSVGLQTSD IVEYLQKLSK TSVPDGIVQF IKLCTVSYGK VKLVLKHNRY FVESAFPDVI
QNLLQDNLIR ECRLRGADGS DPELITEVIH SKSAISKAVQ DKGGASTSQQ PSDGQTSSQQ
VPEDIFSYYE QMDKEEEEEE ETQTVSFEIR QEMIEELQKR CIQLEYPLLA EYDFRNDTVN
PDINIDLKPT AVLRPYQEKS LRKMFGNGRA RSGVIVLPCG AGKSLVGVTA ACTVRKRCLV
LGNSSVSVEQ WKSQFKMWST IDDSQICRFT SDAKDKPIGC SVAISTYSML GHTTKRSWEA
EKVMEWMRTQ EWGLMILDEV HTIPAKMFRR VLTIVQAHCK LGLTATLVRE DDKIVDLNFL
IGPKLYEANW MELQNNGYIA KVQCAEVWCP MSPEFYREYV AIKTKKRILL YTMNPNKFRA
CQFLIRFHER RNDKIIVFAD NVFALKEYAI RLNKPFIYGP TSQGERMQIL QNFKHNPKIN
TIFISKVGDT SFDLPEANVL IQISSHGGSR RQEAQRLGRV LRAKKGMVAE EYNAYFYSLV
SQDTQEMAYS TKRQRFLVDQ GYSFKVITKL AGMEEEDLMF SSREEQQQLL QKVLAASDLD
AEEEVVAGEV GARPQFSRRV GTMSSMSGAD DTVYMEYQSR SNKASAGSKS VHPLFKRFRK
//