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Database: UniProt
Entry: A0A3B3XHF7_9TELE
LinkDB: A0A3B3XHF7_9TELE
Original site: A0A3B3XHF7_9TELE 
ID   A0A3B3XHF7_9TELE        Unreviewed;       780 AA.
AC   A0A3B3XHF7;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=General transcription and DNA repair factor IIH helicase subunit XPB {ECO:0000256|ARBA:ARBA00014343};
DE            EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE   AltName: Full=DNA excision repair protein ERCC-3 {ECO:0000256|ARBA:ARBA00032205};
OS   Poecilia mexicana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000014424.1, ECO:0000313|Proteomes:UP000261480};
RN   [1] {ECO:0000313|Ensembl:ENSPMEP00000014424.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001665};
CC   -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC       {ECO:0000256|ARBA:ARBA00006637}.
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DR   RefSeq; XP_014837396.1; XM_014981910.1.
DR   STRING; 48701.ENSPMEP00000014406; -.
DR   Ensembl; ENSPMET00000022388.1; ENSPMEP00000014406.1; ENSPMEG00000016987.1.
DR   Ensembl; ENSPMET00000022397.1; ENSPMEP00000030420.1; ENSPMEG00000016987.1.
DR   Ensembl; ENSPMET00000022423.1; ENSPMEP00000014432.1; ENSPMEG00000016987.1.
DR   Ensembl; ENSPMET00000022433.1; ENSPMEP00000014444.1; ENSPMEG00000016987.1.
DR   Ensembl; ENSPMET00000022451.1; ENSPMEP00000014452.1; ENSPMEG00000016987.1.
DR   Ensembl; ENSPMET00000022592.1; ENSPMEP00000014424.1; ENSPMEG00000016987.1.
DR   Ensembl; ENSPMET00000032603.1; ENSPMEP00000030436.1; ENSPMEG00000016987.1.
DR   Ensembl; ENSPMET00000032606.1; ENSPMEP00000030440.1; ENSPMEG00000016987.1.
DR   GeneID; 106914831; -.
DR   KEGG; pmei:106914831; -.
DR   CTD; 2071; -.
DR   OrthoDB; 1360679at2759; -.
DR   Proteomes; UP000261480; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR   CDD; cd18029; DEXHc_XPB; 1.
DR   CDD; cd18789; SF2_C_XPB; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR032438; ERCC3_RAD25_C.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001161; XPB/Ssl2.
DR   InterPro; IPR032830; XPB/Ssl2_N.
DR   NCBIfam; TIGR00603; rad25; 1.
DR   PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR   PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR   Pfam; PF16203; ERCC3_RAD25_C; 1.
DR   Pfam; PF13625; Helicase_C_3; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   PRINTS; PR00851; XRODRMPGMNTB.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT   DOMAIN          324..485
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          539..699
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          220..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          761..780
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   780 AA;  88933 MW;  4C6B40184ED9EE26 CRC64;
     MGKRDKEKKS KKRYYEEEDD EDDVTGSEPQ EAVPAAAGKQ VDESGTKLDE YGAKDYRSQM
     QLKKDHSSRP LWVAPDGHIF LEAFSPVYKY AQDFLVAIAE PVCRPNHVHE YKLTAYSLYA
     AVSVGLQTSD IVEYLQKLSK TSVPDGIVQF IKLCTVSYGK VKLVLKHNRY FVESAFPDVI
     QNLLQDNLIR ECRLRGADGS DPELITEVIH SKSAISKAVQ DKGGASTSQQ PSDGQTSSQQ
     VPEDIFSYYE QMDKEEEEEE ETQTVSFEIR QEMIEELQKR CIQLEYPLLA EYDFRNDTVN
     PDINIDLKPT AVLRPYQEKS LRKMFGNGRA RSGVIVLPCG AGKSLVGVTA ACTVRKRCLV
     LGNSSVSVEQ WKSQFKMWST IDDSQICRFT SDAKDKPIGC SVAISTYSML GHTTKRSWEA
     EKVMEWMRTQ EWGLMILDEV HTIPAKMFRR VLTIVQAHCK LGLTATLVRE DDKIVDLNFL
     IGPKLYEANW MELQNNGYIA KVQCAEVWCP MSPEFYREYV AIKTKKRILL YTMNPNKFRA
     CQFLIRFHER RNDKIIVFAD NVFALKEYAI RLNKPFIYGP TSQGERMQIL QNFKHNPKIN
     TIFISKVGDT SFDLPEANVL IQISSHGGSR RQEAQRLGRV LRAKKGMVAE EYNAYFYSLV
     SQDTQEMAYS TKRQRFLVDQ GYSFKVITKL AGMEEEDLMF SSREEQQQLL QKVLAASDLD
     AEEEVVAGEV GARPQFSRRV GTMSSMSGAD DTVYMEYQSR SNKASAGSKS VHPLFKRFRK
//
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