ID A0A3B3XN75_9TELE Unreviewed; 832 AA.
AC A0A3B3XN75;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Sushi domain-containing protein {ECO:0000259|PROSITE:PS50923};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000016489.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000016489.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR AlphaFoldDB; A0A3B3XN75; -.
DR STRING; 48701.ENSPMEP00000016489; -.
DR Ensembl; ENSPMET00000033410.1; ENSPMEP00000016489.1; ENSPMEG00000019213.1.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd00033; CCP; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR PANTHER; PTHR11475:SF60; THYROID PEROXIDASE; 1.
DR Pfam; PF03098; An_peroxidase; 1.
DR PRINTS; PR00457; ANPEROXIDASE.
DR SMART; SM00032; CCP; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 1.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
DR PROSITE; PS50923; SUSHI; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT DOMAIN 753..809
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT BINDING 482
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ SEQUENCE 832 AA; 92410 MW; 5BF6F0748CD53E19 CRC64;
MSPSCCSSCL WSHIKTRLLP GRRGAMKTKK CFHLSLLVML VCVVPPTPST LSSSSLRDFL
VSSPQDADGA SSQRRRAAPL CSHGFRFHFQ PQTQEISRSG EIFHAALQIL KNAAKQKYNR
NFTASELLSQ ENLELLAELS QCPTETDPAV CEGSHHDKYR SISGVCNNRQ NPDWGAANTA
LVRWLPAEYE DGEEEPRGWD PQRLHHGSQL PLPRRVSREV VRTSCKDADA AYSQLLADWG
QYIDHDVTLT PQSLSGAASW TQRDCRTSCE NLHPCFPIQT QDSLCMPFQR STPACCSRAG
SGMQRQQLNA VSSFIDASLV YGHTPQLQSD LRDLSGRSGK LAVNGRFQDR QGRPYLPFVA
ETPSACGAAG RGRGVECFRA GEARVNEGLP LIVLHTLWLR EHNRLADTLK LINQHWSPEA
VFQEARKIVG ALHQIITMRD YIPKVIGAES FERHIGPYGG YDPTVDSSAS NVFATAAFRF
GHATIPPILS RLNESFQEDR RFPHLRLQQA LFSPWRIVKE GGIEPTLRGM VATAAAVAAP
DSLLVEEVTE SLLVLDSQQN LDLAALNLQR GRDHGLPGYN DWRGFCGLKR IATLDDLAEV
VRDRRVAEKI LHLYQHPDNI DVWLGGLVEN FLPGSRTGPL FACLIGKQMK LLRDGDRFWW
EADGMFTQQQ REQLWKTSLS RIICENSDIQ EIPADPFRLT RYPDGFLPCS AVPALSLEAW
RDEPSLGEFT DRSHSLQTFN MPTTQTAAVS GLRLCGSPRP VDNGDFLFSS RSGKLTALYA
CFHGFQLEGA AEAVCEGGVW SADPPCCSET RLVARDAADP QTFLDSNQTN KT
//
