ID   A0A3B3XRH6_9TELE        Unreviewed;      1199 AA.
AC   A0A3B3XRH6;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
OS   Poecilia mexicana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000017684.1, ECO:0000313|Proteomes:UP000261480};
RN   [1] {ECO:0000313|Ensembl:ENSPMEP00000017684.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747,
CC         ChEBI:CHEBI:16113; Evidence={ECO:0000256|ARBA:ARBA00034049};
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   AlphaFoldDB; A0A3B3XRH6; -.
DR   Ensembl; ENSPMET00000026616.1; ENSPMEP00000017684.1; ENSPMEG00000021464.1.
DR   Proteomes; UP000261480; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030301; P:cholesterol transport; IEA:UniProt.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR032190; NPC1_N.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR   PANTHER; PTHR45727:SF3; NPC1-LIKE INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR   Pfam; PF16414; NPC1_N; 1.
DR   Pfam; PF02460; Patched; 1.
DR   Pfam; PF12349; Sterol-sensing; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        275..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        589..610
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        622..646
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        652..675
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        695..722
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        728..753
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1018..1038
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1044..1064
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1071..1091
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1111..1135
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1147..1172
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          588..753
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   1199 AA;  132548 MW;  B9438E6CC4D6887F CRC64;
     NAEAMKEKKA SSEVEHRAGY CAFYDECGRN PTVGESLIPP IVPCLNYSRA RQVTGDHYRR
     LKQVCPMLDF GESNTYACCS LQQIASLETS LTLSKAVLIR CPSCADNFAH LYCATTCSPN
     QTLTVNVTKV MNVTHLGRPR DAVVAYQAYI SSTFAEGAFQ SCKNVRIPAT GGFAIATMCG
     RYGSKLCTAQ RWYDFQGDTS NGLAPLDIDF RLLKENDTTG VPEGMIPYNG RALGCNENTT
     TGGMACSCQD CLDSCPRVPP PPPLPEPFRI QGMNGFLVIS IILLCLLICA FVVYLIVSHY
     VKSKNGKNLK VTCVLLVAAI IVVVFSVGLK SIKLTTDPVE LWSAPNSRAR QEKDFHDKHF
     TPFFRTNQLI LTAPGRKGHL YDSLLFGKQN FSGLISKSLI LELLDLQRRI QFWSEDLNRT
     ATLKDVCYAP LNPSNPSLTD CAVNSLPQYF QNSLDNINAK VNMTELGVTQ EVDWRDHLIY
     CLNSPLSFKD ITDLGMSCMA DYGAPVFPFL AVGGYKNDEY TNAEAFILTF SLNNYLRDNP
     KFKVALQWET EFLKIVQDYQ RNPKANFTFA YMAERSLEDE INRTTAEDIP IFMISYAVIF
     VYIAVALGEY SSCKRLLVDS KFLVGLGGIL VVGCSVLASM GFYSWIGIPS SLVILQVVPF
     LVLAVGADNI FIFVLEYQRD ARRLGETREE QIGRVLGQVA PSMLLCSLSE SVCFFLGALS
     TMPAVKSFAL YAALAVLMDF VLQMTAFVAL LSLDARRQDN NRCELLCCVT VSTRRPNKPN
     EGFLLPFMRK YYAPVLLHLG VPVYFVTKKG YNFNTVEGMD GVCSSVGCDQ FSMTQKIRYA
     TDYPERSYMA IPANSWVDDF IDWLNPGSKC CRLYTSGPNA GNFCPANITG LSCLKKCLAS
     PSDGVVRPTM EEFSRFLPDF LGNRPDLQCS KGGLGAYDTA VVRDQNGEII ATRFMAYHTP
     LTNSQEFTAA LLKARELAKK ITSDMRKIPG TSPDFEVFPY TITYVFYEQY LTIVKEGLFN
     ISLCLLPTFV VCCLLLGLDL RSGLLNLITI IMIVVDTVGV MTLWSIDYNA VALINLVTAV
     GISVEFVSHM TRSFALSTKM TRVERAKEAT ATMGSAVFAG VAMTNLPGIL VLAFAKAQLI
     QIFFFRLNLV ITLLGMAHGL VFLPVLLSYF GMNIYRCVAG SLSFGGETCV TPAASYGNH
//