ID A0A3B3XRP4_9TELE Unreviewed; 591 AA.
AC A0A3B3XRP4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000017600.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000017600.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:83421; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001512};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class CDC14 subfamily. {ECO:0000256|ARBA:ARBA00007315}.
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DR RefSeq; XP_014850644.1; XM_014995158.1.
DR STRING; 48701.ENSPMEP00000017600; -.
DR Ensembl; ENSPMET00000026483.1; ENSPMEP00000017600.1; ENSPMEG00000020430.1.
DR Ensembl; ENSPMET00000026487.1; ENSPMEP00000032528.1; ENSPMEG00000020430.1.
DR Ensembl; ENSPMET00000026492.1; ENSPMEP00000017601.1; ENSPMEG00000020430.1.
DR GeneID; 106922595; -.
DR CTD; 565969; -.
DR OrthoDB; 9871at2759; -.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14499; CDC14_C; 1.
DR CDD; cd17657; CDC14_N; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR044506; CDC14_C.
DR InterPro; IPR029260; DSPn.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR23339:SF121; DUAL SPECIFICITY PROTEIN PHOSPHATASE CDC14AB-RELATED; 1.
DR PANTHER; PTHR23339; TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE; 1.
DR Pfam; PF00782; DSPc; 1.
DR Pfam; PF14671; DSPn; 1.
DR SMART; SM00195; DSPc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912}.
FT DOMAIN 177..335
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 260..322
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 395..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 591 AA; 65469 MW; D43DD2A5FC6E1346 CRC64;
MAEEREPRGA AELIKDRLYF ATLRSKPKST VNTHYFCTDD EFVYENFYAD FGPLNLAMLY
RYCCKLNKKL KSFTLTRKRI VHYTSFDQRK RANAAVLIGG YAVIYLKKTP EEAFRALISG
SNAAYLPFRD ASFGNCTYNL TVLDCLQGIR KALQHGFFDF ETFDVDEYEH YERVENGDLN
WIVPGKFLAF SGPHPKSRIE NGYPLHAPEA YFPYFRKHGV TTIIRLNKKI YDGKRFTNAG
FDHYDLFFID GSTPNDTIVR RFLHVCENAQ GAVAVHCKAG LGRTGTLIGC YLMKHYRFTA
AEAIAWIRIC RPGSIIGPQQ NFLEDKQASL WLQSQHTLKG RTEDKTAHLI SGLDELSLSS
AHNANFLRSA SAERLQEGDI TDGSGLTQGD KLRALKSRRH PRPSVSGGAV RFEESKSHHR
PSSPPLRLSK GSSQSPASIL KPSKLPASST SPAAKRIGRN SLSPMSNIRS SAFGSRLASS
LGDLYAADAE EDEKTPFSSL PPSSSVSVSP APSAPSPGYS GGPRGAQHEV NNNSTLYGGS
AAPPVVKGYM RPQHQDVSAF RGHGPYSAMK GPSGRYLSRS IPSLQSEYIQ Y
//
