ID A0A3B3XSP7_9TELE Unreviewed; 310 AA.
AC A0A3B3XSP7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=TNFR-Cys domain-containing protein {ECO:0000259|PROSITE:PS50050};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000018046.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000018046.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR AlphaFoldDB; A0A3B3XSP7; -.
DR STRING; 48701.ENSPMEP00000018046; -.
DR Ensembl; ENSPMET00000027253.1; ENSPMEP00000018046.1; ENSPMEG00000021018.1.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR048522; Death_3_fish.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR PANTHER; PTHR23097; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER; 1.
DR PANTHER; PTHR23097:SF181; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21-LIKE-RELATED; 1.
DR Pfam; PF21733; Death_3; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00206}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..310
FT /note="TNFR-Cys domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017362223"
FT REPEAT 69..109
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 69..109
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 110..151
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 110..151
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DISULFID 70..85
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 88..101
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 91..109
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 310 AA; 34412 MW; D97ECEC61AA240AC CRC64;
FSSHVQHVKL SLCVLIILLS SWLANGVASQ LTYEVTDPIT GKPLQCDRCP PGTFLRASCS
SIKERECAPC PQGSFTELWN YIGRCLRCGV CGRNQVVKKE CTAISDCQCE CKPGYFYSQD
YDMCVRHSEC PSGQEVLTKG TVTSENTDTV CSVCSEGSFS DISSAHQNCT QHKNCSDAGL
QLVLRGSSWH DILTTCFLSD GAEYLKEIIP PFFIHHKMNI KRLRRIVHRL PSEDGRKARE
TRELNFSELH SRICSWVSSA TAAQIQQLPD IVNKMGATGA SEKLQSKLNS IQTHLTEHCQ
SEILSNAILS
//
