ID A0A3B3XT85_9TELE Unreviewed; 706 AA.
AC A0A3B3XT85;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Pleckstrin and Sec7 domain containing {ECO:0008006|Google:ProtNLM};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000018241.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000018241.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, ruffle membrane
CC {ECO:0000256|ARBA:ARBA00004632}.
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DR AlphaFoldDB; A0A3B3XT85; -.
DR STRING; 48701.ENSPMEP00000018241; -.
DR Ensembl; ENSPMET00000027301.1; ENSPMEP00000018241.1; ENSPMEG00000021154.1.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13295; PH_EFA6; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF334; PH AND SEC7 DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF01369; Sec7; 1.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
FT DOMAIN 211..377
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 428..541
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 139..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 706 AA; 79236 MW; 89CB2A079E7605B9 CRC64;
MVSWASVRMQ GDSRKQRFAA EEDPEVFGHL LTRPMETFFD NHNPALKSPI LVSGPRCAAE
DTFSSHFESI MESHRAKGTS YNSLDSEELL TSSTQTVLSF DLPTLTPAIH GPVCQSARQI
VQLSFAPLAH HERPSLSDSI FTVTGDSDAT RAPSSERLSS GSDDVMPRGR ECAQLGSSWY
INPSFSLSSR EKARLATDSE LDQDLSDRLG LGSSDTLTNG SHRGDVAAAK RLAKRLFHLD
GFRKSDVSRH LSKNNDFSRM VAEEYLSFFS FTGLTLDQAL RTFLRQFALM GETQERERVL
SHFSRRYLEC NPKVLPSEDA AHTLTCALML LNTDLHGQNI GKRMSCTQFI GNLEGLNGGQ
DFPKDLLKAL YNSIKNQKLQ WTLDEEELRK SFSELGDSLL ESDASRPMKR VGSSGKPLSD
GMEPTGMLLY KNGFLVRKVH ADSDGKRTPR GKRGWKTFYA ILKGLILYLQ KGEYRPDKQL
SDEDLKNAVS IHHSLAMKAS DYSKRPNVFY LRTADWRVYL FQAPNAEQMQ SWITRINTVA
AMFSSPPFPA AIGSQKKFSR PLLPGTMSKL SEEEQIRSHE ARFRAVSTDL AELRSFPPDR
KVKGRELEEY RLRDEYLDFE KTRYGTYVML LRAKIRSGEE DLSVFESLLL EDSSLQRAHS
SPTLQDSSLA SQASSSRGTS SKASACSSSK PRQEGQRNSY RQAVKK
//
