ID   A0A3B3XUK7_9TELE        Unreviewed;      1850 AA.
AC   A0A3B3XUK7;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=SET binding factor 2 {ECO:0008006|Google:ProtNLM};
OS   Poecilia mexicana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000018757.1, ECO:0000313|Proteomes:UP000261480};
RN   [1] {ECO:0000313|Ensembl:ENSPMEP00000018757.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR   Ensembl; ENSPMET00000034339.1; ENSPMEP00000018757.1; ENSPMEG00000022082.1.
DR   Proteomes; UP000261480; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   CDD; cd13339; PH-GRAM_MTMR13; 1.
DR   CDD; cd01235; PH_Sbf1_hMTMR5; 1.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR004182; GRAM.
DR   InterPro; IPR037823; MTMR13_PH-GRAM.
DR   InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR   InterPro; IPR030564; Myotubularin_fam.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR022096; SBF1/SBF2.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR   PANTHER; PTHR10807:SF4; MYOTUBULARIN-RELATED PROTEIN 13; 1.
DR   Pfam; PF02141; DENN; 1.
DR   Pfam; PF02893; GRAM; 1.
DR   Pfam; PF06602; Myotub-related; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF12335; SBF2; 1.
DR   Pfam; PF03456; uDENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   SMART; SM00568; GRAM; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00800; uDENN; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   PROSITE; PS50211; DENN; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE   3: Inferred from homology;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658}.
FT   DOMAIN          7..423
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
FT   DOMAIN          1111..1587
FT                   /note="Myotubularin phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51339"
FT   DOMAIN          1744..1848
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1054..1107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1093..1107
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1850 AA;  207270 MW;  72B77CAB292BA116 CRC64;
     MCKLACFFFR YLSVPAGSGE GCGKIIQRFP KKDWEGTAFP QGVEMFCQPG GWRLSRERKA
     PTFFTVVLTD IDSDRHYCSC LTFYEAEVNL QADGDEDEEA EEDGLIQPAQ VFAPKSLILV
     SRLDYPEIFR GCLGLIYTVY IDSLNFPLEG LVANLFIFQV PVAGGSQKLF SLGAGDRQLI
     QTPLNDTLPV TFKSVALLFQ QLGIQNVLSL FCAVLTEHKV LFHSSSYQRL GEACRAVEAL
     MFPLRYSYPY IPILPSRLLE VLSSPTPFII GVHSMFQNEV QDLLDVIIAD LDGGTIKIPE
     CIHLSLLPEP LLHQTQSTLS LVLHPDLEIA DNAFPPPRTA PSNLKLLDKE VRAVFLRLFA
     QLFQGYRSCL QLIRIHSEPV IHFHKTAFLG QRGLIENDFL TKVLDGMAFA GFVSERGPPF
     RACDLFDELV ALDVESFKEE EANPVMLQKR IRELSEQLFR NENPNPHMAF QKVPRPSEGS
     HLRVHQVPFP LLDDEKVEKM LQDGVAKHSL TPVSTRPEKK CVVPAGPAVV SIMGKCGSVF
     NSARRLEVVK SCISFIFDNK TLETEKTLPA ALRALKGKAA RQCLTDELSV HVQQNRAILD
     HQQFDYIVRM MNCALQDCST SEEFTVAAAL LPLSTAYYRR LAAGVNQFAY TCIQDHPIWT
     NQQFWEATFY SEVQTVLSKS FLNKDELIDP HQGVKLFLLL LALQDADPQS AAGNDEEQTA
     MDLAAQQLRL WPSLSKDKQQ ELVKNEENTV FSQAIHYANL MVYLLVPLDT SKNKLLRNAP
     VTDWESGSNS IVTNSIAGSM AESFDTESGF EDSENSDTAN SVVRFVARFI DKVCTESGVT
     QEHIKSLHCM IPGIVAMQME ALEAVHRESR RLPPIQKPKI LRPALLPGEE VVSEGLRVLL
     DPDGREEATG GLLGGPHILP AEGALFLTTY RIIFKGIPHD PLVGEQAVIR AFPVSTLTKE
     KKISIQNQLQ QNMQEGLQLR SASFQLIKVA FDEEVSSEVV EIFRKHLQRI RYPQSIFSSF
     AFAAGQTAPQ LILPKPKERN TGFRTLSKTI VKGAKRAGKI TMGRGSQSSL KKADRGSRMT
     WQEDDDISIS DDGEPPPSST LRASEKSTME QLVEQSCFRD YQRLGLGTIT VSSSRSKSGD
     QFRITAVNRL YSLCRSYPGL LVVPQAVQDS SLHKVARCYR HNRLPVVCWK HPRTKAVLMR
     SGGFHGKSVV GLFKSQNTSS ASPASSSDSS SSLEQEKYLQ AILDSIPTIF KINGTNTLSN
     RSLIGLSPGM WASLRSSGRL SQHPSQGDVG ARLAGKNLAP PAGSNSLQAQ LRKHRAAFYI
     FGEKSHLRGL RLDSSLNCEL VPVEFADARQ VKAAFKKLLR ACAPSAPFSD SEDSFLKALE
     ESEWMLQLHK ILQLALSLVE LLDSGSSILL SLEDGWDITT QVVSLIQLLS DPFYRTLEGF
     QVLLEKEWLS FGHKFSQRSN LSPSSQGSGF TPIFLQFLDC VHQILDQHPM EFEFNQYYLK
     FLAYHHNSNR FKNFLLDSDY ERLEHGLLFE DKVDKQGRRG ICIWDCINRM HRRSPIFFNY
     LYSPSESEVI LKPCVSIPSL TKWDFFTEET LSTGPCYDWR MMAVRSESTE EADANANSKR
     RIVWPCYSNV SSAQPDAITK LLTVSDIERL EGELNQGPEK WQTTLERVRL SILEDLKQEG
     NLRKQSLSLS GLIPTSSLQA FQRRSMLHLP DSGLGDDHST ATANGINRRA ATLYNQFTPK
     NEENRSYEGI LYKRGALLKA WKPRWFVLDV TKHQLRYYDT GEDTNCRGHI DLADVESVTP
     AAPTIGAPKH ISEKAFFDLK TNKRVYNFCA SDAPSAQVWM DKIQSCVSDA
//