ID A0A3B3XUY4_9TELE Unreviewed; 1669 AA.
AC A0A3B3XUY4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=SH3 and multiple ankyrin repeat domains 1 {ECO:0008006|Google:ProtNLM};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000018887.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000018887.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Postsynaptic density
CC {ECO:0000256|ARBA:ARBA00034105}.
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DR STRING; 48701.ENSPMEP00000018887; -.
DR Ensembl; ENSPMET00000028135.1; ENSPMEP00000018887.1; ENSPMEG00000021941.1.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd09506; SAM_Shank1_2_3; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24135; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN; 1.
DR PANTHER; PTHR24135:SF3; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT REPEAT 165..198
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 199..231
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 299..331
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 456..515
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 551..645
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1606..1669
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 762..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 847..970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1032..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1286..1330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1513..1550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..781
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 882..902
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 913..960
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1047
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1050..1098
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1114..1134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1311..1328
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1527..1541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1669 AA; 183239 MW; 24EF608FB0810B5D CRC64;
MDRPLRPGNL DNRGIAHMSN QAQTHHHAAN KLQQQHLMRC LQFDQDCTVW SAKQQIVCSL
GESLWDVYNY GLFQPAGEGR DAKFLEEERP LRDYARTFEK GVPYLEFRYK TRVYKQTNLD
EKALAKLSTK ASQKKFLEYV QTGVMEKMAK VLEKGLDPNF HDPDSGETPL SVAVQSGLPV
DGVRLLVLGG AHMDFRSHDG MTALHKAVRA HNHAGLLALL SLGASPDYKD RCGLTPLYHT
VLTGGETSCC ETLLYYRAKL GTRDENGWDE SHQACQNGFA QHLEHLLFYG ADTASQNASG
NTALHISALY NKESCVRVLL YRGANKEAKN KHGQTPFQVA VMSGHFELGE IIKNHKDTDV
GTFPGKLLCR KLKSVIWVIE PEFLHFRKYI VHLLTYKGRI ELFTSFFIYC IERYKWLNEK
SGELVVETLW FGPVSVCLTR SAAPGGGQMK RMYSAVPGRV YVAIRSHSAS GDRELSLNKG
DKVKVLSVGE GGYWEGTARG RTGWFPSDCV QEVAPPKTRS EKAKRKLFRN VTVGAYDGTD
GPSDYIIKEK TVLLQKKDNE GFGFVLRGAK AQTPIEEFTP TPAFPALQYL ESVDEGGVAW
RVGLRMGDFL IEVNGQNVVK VGHRQVVNMI RQGGNSLMVK VVMVARNPEL EDTARKKAPQ
QSKRLTPPAI ALRSKSMTSE LEDMGETDPQ FRFGYNQAHF QPGHGPQHAV MMRQKSIGNH
TSSTDFFRFL FLAVTMSFWA LGVTEEERQY LHPPAMKLAR SLSVPGPEDI PPPPNTSAPE
PPLSAGPYTG RGPAMPIPPV SQAHYQLHSQ PAHPTQAAWE RGGPGGMNQQ VMVPTLRRQS
DGLCIREPEA PRRGGGKMGG LRRGYSGGAG RGVARRGGRG ALIKQSKVED GLRQHRGKGG
ATKEKSSIPI PTIIVKAPST SSSGRSSQGS SIEAELSQDV EDQSSGNAAP DNSSTNIQGE
AGGGEGGGTL EAQVQPLQEY SSPVLGQDGQ PKSAPSVYGS QPATTFIHPL TGKVLDPSSP
LGLALAARER ALKDDRRTRR DDRHFGRQMS TVGSFPTPIQ TPTPSLFATP TQSAYTSPVS
LHLGSPSATA SPASLSRPQS PRILRLGGGG GGGGERMERE RDGGPKEGLR VRFSEDRNSQ
FSGQYYPQSS REREKEMYES KHAQAVQPPP PPAQPAPRRP SYLQMENVPN TSYIPQYTVP
TAPSQTNDAM GEARAGAGGL GLMVLPPPAP SIDVDEEFVF ADPLPPPLQF ANGNLHFLHR
IRPRKYLHLR PPPPPPQRLL CLPHHYTDPS PSSPASSDYS MAGPKVGLST GSKGTDPTHS
STMIPKSGDW QDTVVDSGIE ELDSHSSSDH HLEMLGLGGL RGEKIGLGGD GREGEGEKVN
EHQDPCTIYR GGQPFEVHTS KIANPVFPKM TKHKQSRARM EDGFSSALAA CLERPIEPRS
VVWGDITEHE LHSPFSGVKA SIINELSSKL QQMSSMRSMD DWSHVPKSPS MHRFVCFDQL
LCKVPLTSMA TSYPSKEMRS SVSRRRAPSP LIYNTEQQNP TPPRPSSLPI LPSTPIYSNP
FDFPGPLTPP SPVSRSLSPT HFFSGASSPF PAPPAKPFAI KPLPYWTKYD VADWLTYLNL
GEHRERFIDN EIDGSHLPSL TKDDFLDLGV TRVGHRMNIE RALKKLTDR
//
