ID   A0A3B3XW80_9TELE        Unreviewed;       837 AA.
AC   A0A3B3XW80;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=G-protein coupled receptor family C group 6 member A {ECO:0000256|ARBA:ARBA00039774};
OS   Poecilia mexicana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000019160.1, ECO:0000313|Proteomes:UP000261480};
RN   [1] {ECO:0000313|Ensembl:ENSPMEP00000019160.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3B3XW80; -.
DR   STRING; 48701.ENSPMEP00000019160; -.
DR   Ensembl; ENSPMET00000028461.1; ENSPMEP00000019160.1; ENSPMEG00000022155.1.
DR   Proteomes; UP000261480; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR   PANTHER; PTHR24061:SF5; G-PROTEIN COUPLED RECEPTOR FAMILY C GROUP 6 MEMBER A; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   PRINTS; PR00248; GPCRMGR.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        578..599
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        606..626
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        638..662
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        674..698
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        725..745
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        757..781
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        787..807
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          596..820
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
SQ   SEQUENCE   837 AA;  93547 MW;  495C4898DED4F9BA CRC64;
     MRRAFQEKAH TAGVESTACT SDSTMFLLKL LVTFMSVFHF SSENTDLHAY LDGDVIIGGL
     FPVHAKTNRT TDPGPINCTA FNIQTFLRTQ VMIYSIQEIN QRTPRLLPNL TLGYDIYDTC
     GDVSLAIRAT LQLLKDQSDP QRCLIPASIN SSLPEPETKV VIGEAFSEVS VAVARVLALP
     SISYASTSEQ LSLKYKFPTF LRTVSSDKHQ TQAIYELVKN FSWQSVAIVG SIDGYGKFGT
     DSLMQLFSDN NICVDFVEIL PDTFDKNCST ARHLLEKIEN STAEAIIMFT QEINVQIILE
     AVIEKNLNRT WIASDTWSTS STISEKKGIK SIGPVFGFIF RQKEVPGFKD YVTSMFNGTT
     NNILSYYQVF TNGSKDDMKC NCKNKTADPS CLYCYIDHDE SYNIYMAVQF IAEGLRILLK
     CNNQSCERTK FSAVEVNKLI MILDQNINIT VNDTNIYFDE NGDPSLGYDI LFWNTSESKE
     GHPVLILLSL SQVSVFNCSR TCQPGQRMEL QNGKCCHGCV DCSPQEYSNG NGQCYICYLF
     CFCLKYNFIL SYFICHQFEA IRSEALGLYQ DNDPKRTIVP LLFPMIAIVI GLNCGTPIVK
     AIGGCLCYVE MASLLLGFCT TFTFIGKPTQ NSCVGIPIFG ISFSLCISCI LANLIQILLG
     FSFDPRVGSK IKKLNHPVAV VVIISGVQLG VSLAWLIVLP RLPSVEQKES TILYQCNMSE
     ESKKFFAATI VYNSFWGLVC FVFAFKGRQL PDIYKNASLI TVSMVLFLII WIVFLPIYLT
     LDGKYKPAIS SAAILISCIS ILGCHLAPKC YIMLFRKEIN NQNAIKFCDF MSMKSTL
//