ID A0A3B3XWM7_9TELE Unreviewed; 3761 AA.
AC A0A3B3XWM7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Zinc finger homeobox 4 {ECO:0008006|Google:ProtNLM};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000019456.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000019456.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_014837150.1; XM_014981664.1.
DR RefSeq; XP_014837151.1; XM_014981665.1.
DR RefSeq; XP_014837152.1; XM_014981666.1.
DR STRING; 48701.ENSPMEP00000019456; -.
DR Ensembl; ENSPMET00000028842.1; ENSPMEP00000019460.1; ENSPMEG00000022456.1.
DR Ensembl; ENSPMET00000028847.1; ENSPMEP00000019456.1; ENSPMEG00000022456.1.
DR GeneID; 106914695; -.
DR KEGG; pmei:106914695; -.
DR CTD; 79776; -.
DR OrthoDB; 4180951at2759; -.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00086; homeodomain; 4.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR Gene3D; 1.10.10.60; Homeodomain-like; 4.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45891; ZINC FINGER HOMEOBOX PROTEIN; 1.
DR PANTHER; PTHR45891:SF2; ZINC FINGER HOMEOBOX PROTEIN 4; 1.
DR Pfam; PF00046; Homeodomain; 4.
DR Pfam; PF00096; zf-C2H2; 1.
DR Pfam; PF12874; zf-met; 2.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM00389; HOX; 4.
DR SMART; SM00355; ZnF_C2H2; 23.
DR SMART; SM00451; ZnF_U1; 7.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 7.
DR SUPFAM; SSF46689; Homeodomain-like; 4.
DR PROSITE; PS00027; HOMEOBOX_1; 2.
DR PROSITE; PS50071; HOMEOBOX_2; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 1515..1538
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1659..1690
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1711..1740
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 2064..2092
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 2257..2317
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 2354..2414
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 2442..2471
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 2720..2780
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 2792..2820
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 3036..3096
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 3544..3576
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DNA_BIND 2259..2318
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 2356..2415
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 2722..2781
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 3038..3097
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 855..894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1253..1332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1405..1488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1602..1641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1737..1824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1921..1955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1971..2014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2112..2202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2500..2593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2675..2727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2819..2908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2928..2954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2989..3044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3179..3202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3243..3353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3459..3526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3631..3657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3678..3727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..650
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..723
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 855..891
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1280..1294
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1311..1325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1405..1444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1445..1488
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1602..1617
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1971..2005
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2115..2163
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2174..2202
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2501..2519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2551..2576
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2577..2593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2675..2693
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2696..2727
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2827..2841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2859..2908
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2928..2949
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2989..3004
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3005..3031
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3184..3202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3269..3289
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3299..3330
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3474..3499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3500..3526
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3634..3657
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3697..3721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3761 AA; 412273 MW; 544456614CCA8080 CRC64;
MATCDSPPMV SSRQQDYGGQ RLDAAAEDNS VVSTETTVTN STNNQSSPVA IGESENGLGG
PVVSPRRSTT TPTTVSATID PVTDQSRRES FTSGNKGSVT GTSPGVGGGA ALGSDCSAPA
TSPVAPAKEI PCNECSNSFS SLQKYMEHHC PNARLPIAGD HEEDEEVEGM MGEESEDEGE
REVGAADVGD MNSEIEMEED SDVENLCGEI IYQPDGSAFI LEDSKEQRGN QGGLSGALQF
RRLLSPQTFP SAQGNSGQSG LSPGVERLEQ PAAPMSFYPQ IINTFHIASS LGSKSLAADH
PSFPNTSAGG LAGAGPVLHS FRVYDLRHKN DKDYLTAEGA AKNSCVSKDV PNNVDLSKFE
GCVADGRRKP VLMCFLCKLS FGYSRSFVTH AVHDHRMTLN EQEQKLLSNK HVSAIIQGIG
KDKEPLISFL EPKKPPNAVL PHFPSPANFL GPDTGLRGLW NAFHNSGENA DSLQAGFAFL
KGSASSSSTD QTPRTQTMPK AETNPNLGGG AGAHRTLSGS SAAAATGGSL ESRNSDSDFK
GHVRDTCTLQ PNGPDLSQYP PIKREPGTVG EESPEQDEDA YSLGGGVEME ADEEEEQVMT
MAMASQRANS TSSKDFPLLN QSIPPLSNSV LKLSSESKGP ASTSSNVLPV SEKLEMEKSL
LSTALSAGRE RENSNDSTTD GLAGRDGLSP SSNPLDMMML RRDDESPGPL HQNTGNASTP
GTPGTPGTPG PGEGSPGSGV ECPKCDTVLG SSRSLGGHMT MMHSRNSCKT LKCPKCNWHY
KYQQTLDAHM KEKHPESGGS CVYCRTGQPH PRLARGESYT CGYKPFRCEV CNYSTTTKGN
LSIHMQSDKH LNNVQTLQNG GSEAPYNHNH ANPVSSASLG GSCSAPSPSK PKQKPTWRCE
VCDYETNVAR NLRIHMTSEK HMHNMMLLQQ NMKQIQHSLH LGLAPAEAEL YQYYLAQNMG
LAGVKLENPA GSGGPDAQMM INPFQLDPAT AAALGSGLVN NDLSAELRLA SGQLMADDLS
MVSSGGMGGM SSADPSLSAL SPPISDPSLR LYQCAVCNCY STDSLEALNA HINAERALPE
EEWRCVVGDV YQCKLCSYNT QLKANFQLHC KTDKHMQKHQ LVAHIKEGGK ANQWRLKCVA
IGNPVHLKCN ACDYYSNSVD KLRLHATNQR HEFAIRLYKH LQKQDSAYSQ ESCVYLCTLC
DYSTKARLNL VQHARSARHQ QNEGLRKLQL HQQGLGGDDD GLSLHEMFQV KECPASPEEA
AEESERPLRS SSRPGLNLTD RDLTESKRPE RANAMSKEVS SMGKHSLLAD RQIESPPKRP
KSAEGKTSAS EQVQQCPYCN YSSKDANRMQ LHVMSQHSMQ PVIRCPLCQD VLSNKIHLQL
HLTHLHSVAP DCVEKLILTV VGPDTPTPNN VMHPQTGQGK TPSLSNSPTS LTDGSGSVKG
NTSKEDQTSQ DKNELEQQEL KPPKEASEAP DWKRTTGLGH DSKSPDNLQD HLSELQRLQQ
QQQQLSVSDR HVYKYRCNHC SLAFKTMQKL QIHSQYHAIR AATMCSLCQR SFRTFLALRK
HLENGHPELS EAEVQQLIGN LPLNGDITES EARALEEAQA FDHDLDKDDE MDQEDKPSPT
GSDSSSLLDD MGAEPKRTLP FRKGPNFTME KFLDPSRPYK CTVCKESFTQ KNILLVHYNS
VSHLHKLKKV LQEASSPVPQ ETSNSIDNKP FKCNICNVAY SQSSTLEIHM RSVLHQTKAR
TAKTDMSSSG VTGSSGPTPA KSPGPSAQGN TSNSDSARSG TPSCNKENSV EPKETNNSSN
TKTTPTTEHV SAQASSHQSA QSSAQLQLQL QHELQQQAAF FQPQFLNPAF FPHFPMTPEA
LLQFQQPQFL FPFYIPGAEF NLNPELALHS AAAFGMPGLT GSFLEDLKQQ MQQQHQLQQA
QAQQQAQQQH QASQIQSQIQ HQKSQQLQNN KSKMEPNTIS VSEIHMSAEA EDHLDKQESR
TKMESAGDGV SDGVKENKDP KKSKFPEPLI PPPRIVSGAR GNAAKALLEN FGFELVIQYN
ENRQKNQKKS KEGIEQIDFS TDKLECGMCG KLFSNMLILK SHQEHVHSHF FPYVELEKFA
QQYREAYDKL YPINPASPET PPPPPPPPPP PPTAPTPVPT PQPPSTSMTK PQTPVPSPVP
VPHPTTHQTT LQTQPAQPPP PPPPPPQPTA PPAPPQVQLP VPLDLPLFPP LMMQSVQHPG
LPPQLALQLP SMDSLSTDLT QLCQQQLGLD PNFLRQSQFK RPRTRITDDQ LKILRANFDI
NNSPNEEQIQ EMSEKSGLPQ KVIKHWFRNT LFKERQRSKD SPYNFNIPPI TTLEDIRMEP
QVSAHEYYRT DSAINKRSSR TRFTDYQLRV LQDFFDTNAY PKDDEIEQLS TVLNLPTRVI
VVWFQNARQK ARKSYENQAD SKDNEKKELT NERYIRTSNM QYQCKKCNIV FPRIFDLITH
QKKLCYKDED EEGNEDNISE EYTDNPEPPL FKASLAPLEL PKPSQTGTAT SSGSSSPVMA
SPRGPMGKAS PKPDISPETE LKQSEIPPSP VMKSLPEPRP SKACTPQPPP QKAPQPQLSR
PHSQPQAATV PSSPLSLALS SLTNSLPHQM LQYQCDQCKI AFPTVELWQE HQHMHFLAAQ
NQFLHSQFLE RPIDMPYMIF DPNNPLMASQ LLSGGLSQMP SQSSSSMATA VSSGSMKRKL
DDKEENANDK DGGNSSEEQH RDKRLRTTIT PEQLEILYDK YLLDSNPTRK MLDHIAREVG
LKKRVVQVWF QNTRARERKG QFRAIGPSQS HKKCPFCRAL FKAKSALDSH IRSRHWHEAK
QAGFSLPPSP MMSQDNERGE SPNKYNFFDY PQLPSKTEPN DYELPTASST PVKPSEAQVK
NFLSPSSLKA ENCDETEGPN NNSAEASSYD LSKMDFDETS SINTAISDVT TGDECNNNEV
ESLTANGGDK MSDSKKGLLL NSDASNERFQ FSMVSPALSF SGKDCDSYFS SRDDEMDDNN
DRSESSSLAD PSSPSPFGAG NPFNKSGKVN STGDRPGHKR FRTQMSNLQL KVLKACFSDY
RTPTMQECEM LGNEIGLPKR VVQVWFQNAR AKEKKFKINI GKPFMISQGS PEGPRTECTL
CGVKYTARMS VRDHIFSKQH ITKVQETLGN QVDREKDYLA PTTVRQLMAQ QELDRMKKAG
DGLSLPSPQQ QTSAENNNAL HGLSLPSGYP GLSGLPPVLL PGVNGPSSLP VFPPNTPALA
SPGAGMLGFP TPATPSPAMS LSTTPTKTLL QTPPPPPPPP PPPPPASSTP LATVNHTEQQ
GKDAERDNNK KPGDKPPQMK MKDRENDSGS RPDTPSMAKT RERLCPVPGK AGNETPLDAA
QLQALQNALA AGDPSSLLGG QFLPYFLPGF PNCFSPQLPR GVQAGGYFPP LCGMESLFPY
GPAAVPQAAM AAGLSPTALL QQYQQYQQSL QDSLQKQQQQ QQKQLEQHQK QLEQKQQQRP
TPVKTPQSVQ STTTNSFKPK EAIESKDDNK GSSTESTKEE PKTETKRITD FPDAFIVPSV
KHEFICRKCQ MIFADEDSVI RHQKSFCYFG HPFTDPQETV LRKAVSNYTC VACNVVVNGN
EALGQHLQSS LHKEKTIKQA MRNAKEHTRL LPHSVCSPTP NTTSTSQSAA SSNNTFPHLS
RLSMKSWPNV LFQANTARKA ASSSPSASPP PPLSSPSTVT STSCSTSGVP TSLPTESCSD
ESDNELSQKL DDLDNALEVK AKAASGLDAS FSSIRMDMFS V
//
