ID   A0A3B3Y376_9TELE        Unreviewed;       800 AA.
AC   A0A3B3Y376;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
DE            EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
OS   Poecilia mexicana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000021588.1, ECO:0000313|Proteomes:UP000261480};
RN   [1] {ECO:0000313|Ensembl:ENSPMEP00000021588.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6;
CC         Evidence={ECO:0000256|PIRNR:PIRNR001251};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|PIRNR:PIRNR001251};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC       from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676,
CC       ECO:0000256|PIRNR:PIRNR001251}.
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DR   RefSeq; XP_014859762.1; XM_015004276.1.
DR   AlphaFoldDB; A0A3B3Y376; -.
DR   Ensembl; ENSPMET00000014871.1; ENSPMEP00000021588.1; ENSPMEG00000001886.1.
DR   GeneID; 106928190; -.
DR   OrthoDB; 20951at2759; -.
DR   UniPathway; UPA00591; UER00663.
DR   Proteomes; UP000261480; Unplaced.
DR   GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR   CDD; cd01319; AMPD; 1.
DR   Gene3D; 4.10.800.20; -; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR006329; AMPD.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01429; AMP_deaminase; 1.
DR   PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR   PANTHER; PTHR11359:SF3; AMP DEAMINASE 2; 1.
DR   Pfam; PF19326; AMP_deaminase; 1.
DR   PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR001251};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR001251}.
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          210..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   800 AA;  92913 MW;  661F70471A83B3AA CRC64;
     MSDLCGVSGP KTLKPQRSLP GTPVSLSQYP VDLRTSMEEK YKELAEELFT RSMAESEMRS
     APYEFPEDSP IEQLEERRLR LERQISQDIK LEPEILLRAK QDFMKIDSAA DLELMKEKSV
     DTVDVGFKER QMPMEREYQR VSISGEEKCG VPFTDLVDAA KCVVKALLIR EKYIYRSMQT
     FCKTAAHALQ DLGTNSLDLR VYEDIPETPV DADAPVHPPV SETHPYDNQD PNNMPPDTGY
     GCKMVDGVIH VFNKKTNMDK STELDLPYPD LKEYIADMTV MMSLIINGPV KSFCYRRLQY
     LSSKFQMHIL LNEMKELAAQ KKVPHRDFYN IRKVDTHIHA SSCMNQKHLL RFIKRAMKKY
     PDEIVHVERG RGQTLREVFE TMNLTAYDLS VDTLDMHADR NTFHRFDKFN SKYNPIGESI
     LREIFIKTDN HVEGKYFAHI VKEVMYDLEE SKYQNSELRL SIYGRSRDEW DKLAEWAVKH
     RVYSDNVRWL IQVPRLFDVY HTKKQLANFQ EMLENIFMPL FEVTIDPASH PELHLFLEHV
     VGFDSVDDES KPEHHIFNLD SPLPANWTEE DNPPYSYYLY YTYANMTVLN HLRRRRGFHT
     FVLRPHCGEA GPIHHLVSGF MLSENISHGL LLRKAPVLQY LYYLAQVGIA MSPLSNNSLF
     LSYHRNPLME YLSRGLMVSL STDDPLQFHF TKEPLMEEYS IAAQVWKLSS CDMCELARNS
     VLMSGFSHKV KSYWLGPSYY REGPESNDIR RTNVPDIRVA YRFETLTEEL NLITHAVRTD
     ELDGIDEEDT LTMGPVSGGR
//