ID A0A3B3Y443_9TELE Unreviewed; 519 AA.
AC A0A3B3Y443;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=G-patch domain and KOW motifs-containing protein {ECO:0000256|RuleBase:RU369096};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000022096.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000022096.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: RNA-binding protein involved in pre-mRNA splicing.
CC {ECO:0000256|RuleBase:RU369096}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU369096}.
CC -!- SIMILARITY: Belongs to the MOS2 family. {ECO:0000256|ARBA:ARBA00010966,
CC ECO:0000256|RuleBase:RU369096}.
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DR RefSeq; XP_014839323.1; XM_014983837.1.
DR AlphaFoldDB; A0A3B3Y443; -.
DR STRING; 48701.ENSPMEP00000022096; -.
DR Ensembl; ENSPMET00000013594.1; ENSPMEP00000022096.1; ENSPMEG00000002762.1.
DR GeneID; 106915891; -.
DR KEGG; pmei:106915891; -.
DR CTD; 27238; -.
DR OrthoDB; 55448at2759; -.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR CDD; cd13152; KOW_GPKOW_A; 1.
DR CDD; cd13153; KOW_GPKOW_B; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR041993; GPKOW_KOW1.
DR InterPro; IPR041994; GPKOW_KOW2.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR045166; Spp2-like.
DR InterPro; IPR026822; Spp2/MOS2_G-patch.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR15818; G PATCH AND KOW-CONTAINING; 1.
DR PANTHER; PTHR15818:SF2; G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN; 1.
DR Pfam; PF12656; G-patch_2; 1.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00739; KOW; 2.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
DR PROSITE; PS50174; G_PATCH; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|RuleBase:RU369096};
KW mRNA splicing {ECO:0000256|RuleBase:RU369096};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU369096}.
FT DOMAIN 190..236
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT REGION 92..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..258
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..392
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 519 AA; 58523 MW; D5B8863D5F4DFF7E CRC64;
MHCFRSFPLQ TKMASHGEDT VASKAVISDE QAERKTTAVS FGFTKTVNKF KPATGGPPTA
RVEKDYLTGI DRNELQSSKP TEKPKELIIP LIQKNRWSRA GQRGEGNGKP EAAERDGDSV
ESQAVKELIE DSRRQLELWE NGPQSEGSLN LSIPLLMQNK VPDGFEDGDH VKVDLRPESS
TEADYESVPV EAYGLAMLKG MGWKKEEGIG RTFKQDVKPI EHQLRPKGLG LGADRSAIKD
LEPSKRQRPP KPGEEQPKQE ELAMAPGGCV LVGSGAHKDL YGKIEGVDAD NARVVVKLAI
GGKTVTLSQY GVKLVGRKEY EKYSKDLSRL SRAHKEKEKE KEKERQRLEE KEKSSSSDKV
KHKSSEREEG KDERKRKHRE SSQDRDKPPV KEARQAPAPP SWLQRDLKVR FIDKAFKGGR
YYNSKMRVED VLTPFTCVCR TEEGRLLDDV KQNMLETIVP KGEYDAVMVV LGEHRGQVGR
ILQRDKNKCR AMVQLDRYEE KLFTLDYDSI CHYVGASDH
//
