ID A0A3B3Y4B1_9TELE Unreviewed; 582 AA.
AC A0A3B3Y4B1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=HMG box domain-containing protein {ECO:0000259|PROSITE:PS50118};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000021978.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000021978.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TCF/LEF family.
CC {ECO:0000256|ARBA:ARBA00006569}.
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DR RefSeq; XP_014839206.1; XM_014983720.1.
DR AlphaFoldDB; A0A3B3Y4B1; -.
DR STRING; 48701.ENSPMEP00000021978; -.
DR Ensembl; ENSPMET00000013931.1; ENSPMEP00000021978.1; ENSPMEG00000002544.1.
DR GeneID; 106915824; -.
DR CTD; 30556; -.
DR OrthoDB; 5351131at2759; -.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd21996; HMG-box_TCF7-like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR013558; CTNNB1-bd_N.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR024940; TCF/LEF.
DR PANTHER; PTHR10373; TRANSCRIPTION FACTOR 7 FAMILY MEMBER; 1.
DR PANTHER; PTHR10373:SF25; TRANSCRIPTION FACTOR 7-LIKE 1; 1.
DR Pfam; PF08347; CTNNB1_binding; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 329..397
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 329..397
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 395..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..78
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..582
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 582 AA; 63700 MW; BD9A86ABCE055ED6 CRC64;
MPQLNGGGGD DLGANDEMIS FKDEGEQEEK ISENVSAERD LDDVKSSLVN ESENNSSSSD
SEQAERRPQT RPDSESYEKT RDYFGEALRR QQDGGFFKSP HYPGYQFLMF PDLTNPYLSN
GSLSPSARTY LQMKWPLLDV PGSAGIKDSR SPTPGHLSNK VPVVQHAHHV HPLTPLITYS
NEHFSPGTPP SHLSPEILDP KTGIPRTPHP SELSPYYPLS PGAVGSIAHP LSWFMQQQGQ
PMYSIPPGGF RHPYPTLAMN ASMSSLVSSR FSPHMVTPPP HSLHQTGIPH PAIVSPAIKQ
EPSGDNISPS MHAKSPVPSK KEEDKKPHIK KPLNAFMLYM KEMRAKVVAE CTLKESAAIN
QILGRRWHSL SREEQAKYYE LARKERQLHS QLYPGWSARD NYGKRKKRKR ENKPDSKPED
FSIRSKKQCV QYLPSEKMCD SPASSHGSML DSPATPSAAL ASPAAPAPTH SEQAQPLSLT
TKPEGRMHHH FSVPGKASGS ASSSSSSSSS SSSSSSSQPS IAIPVGTLGS QSSTPILTRP
IPFTSLHPSM LSPPSPFHQA ALHSHHSLFQ SQPLSLVTKP TE
//
