ID A0A3B3YA13_9TELE Unreviewed; 1700 AA.
AC A0A3B3YA13;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Regulator of G protein signaling 12b {ECO:0008006|Google:ProtNLM};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000024202.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000024202.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR STRING; 48701.ENSPMEP00000024202; -.
DR Ensembl; ENSPMET00000008230.1; ENSPMEP00000024202.1; ENSPMEG00000006328.1.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd13162; PTB_RGS12; 1.
DR CDD; cd08742; RGS_RGS12; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR046995; RGS10/12/14-like.
DR InterPro; IPR037880; RGS12_RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45945:SF1; REGULATOR OF G-PROTEIN SIGNALING 12; 1.
DR PANTHER; PTHR45945; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR Pfam; PF02188; GoLoco; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00615; RGS; 1.
DR Pfam; PF16613; RGS12_us1; 1.
DR Pfam; PF16611; RGS12_us2; 1.
DR Pfam; PF16612; RGS12_usC; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00390; GoLoco; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00455; RBD; 2.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50877; GOLOCO; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50898; RBD; 2.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 47..124
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 316..429
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 875..992
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 1120..1190
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 1192..1262
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 618..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 999..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1080..1120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1273..1337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1377..1430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1444..1481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1511..1637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..580
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..693
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..740
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..789
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1009..1024
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1054
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1081..1104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1278..1293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1377..1420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1511..1531
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1617..1637
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1700 AA; 185304 MW; 2365822729D251DF CRC64;
MEKRRFPGTM SRQVDSSSKR RPCVGSGLAF PQPPQLASTA QYGRIQAVEV ARGRTGYGFT
LTGQSPCVLS CILKGSPADY VGLRSGDCIL SVNDINVSKA SHEDVVKLIG RCSGILNLVI
AEGERHRRHP QRAAGSRHHS SNTMTAAYLD SCSSDDELDV FYNNGVGNNN GRSGCGPKGG
WYKPKVDSKQ LGINRAEKVV AELQSGGIFN MIFENSSHSS SSSDKDRPGV SSSSKPHQMS
DPEFNPYRSA SCTQSNPNLL SEEEMAQVLN DDSVFLESDF RHLHIHHHEE QDMDVGEGAD
FGLEPSEGIL NVGMIVGYLG SIELASTGTN LENDSLQAIR GSMRRLRAEQ KIHSLVLMKV
MHDSVLLCSD RGQVLATYPA EKLAFSACCP DDRRFFGLVT MQATDDHDDR HFSNGRDDEG
SLRTSCHVFI VDPELCHHQV HSGVARRFGF ECTPDPDTGG CLEFPPSSQP LLQFVSVLYR
DMGDNIEGVR ARAFHDPDND AQQNHSTSSN SDSGIGNFLP EEKSNRVLLV DLGGPPSHNH
MSGARQWDSP PSSQQAWSPI LGAAASHPPP PPPPPPMLRN GHYLHDPHLA DLPHPLPLAH
PDLPSRLSQG LNVHHYPARK LGGAMGGGDR RGGGGGVGVE PQRWLPVHVL RDWRQQHQQH
QHHHSHFQGL SSDQESYAES TDGWSSANCS TLPPPMNKIP ADRYRAPLAP GDRMHPPGVS
HPSPPPPPPP PPPPPPPAHL HSHRLAAQKD EWAKKLFGAG DRERSGARRA EKEKKREANS
KEGEKKGGRF RGLTMGFPPL PQRSSARRSF GRSKRLSMAR SLDNLESAAV SDGELNSVEL
QGCSSDNSLN SNASLPSVQS HRRHTERRVA SWAVCFERLL QDPVGVRYFS EFLKKEFSEE
NILFWQACEF FSHVSENDNK QLSQRAREIY NSFLSSKATT PVNIDSQAQL ADDILNAPKP
DMFKEQQLQI FNLMKFDSYT RFLKSRLYQE CMLAEVEGRP LPDPYHIPSS PTSKHSTTGS
DRSNLSTPKK EDKKTKSGRS LNEDSRDDSG DRRKGMFFSW SRNRSFGKGP KKRELADFNY
STNGRRESQG SLSSGASLEL GTSGSGKNEH ERGGGSAPLR QCNISLPDGS CCPVPLRPGM
SIRDLLQGLC DKLCINLAAI DLFLVGGEKP LVLDQDCMTL SSRDLRLEKR TLFRLDLVPI
NRSVGLKAKP TKPVTEVLRP VVAKYGLHLS DLVARISGES EPLDLGLPIS NLDGLRVVLD
TEENAMGKDK IKAAQSHLPA SASRNQSATG DDRPTRKGGS AHPHGENGKA GPGPGTSSQP
LPNHSVSLHK APGKRKQKKI NIDEAEEFFD LISKAQSNRA DDQRGLLNKS DLQLPDFLRL
TPTSPTTPAP LNAEPICSTP NSRNTDNGGF PSSSHRGNKG NGNHRGGVVS GSYLLSASHQ
SQSLDSALGA ECGGGRKTRP PPPFPATVSP IQSTRPGAQG LLQDSATGES IQMLEEDALS
DLTLVGEGDI NSPSLNYITP SSLSSKPLPR PQHQAQDGRP CSGKDRAGWR GREKGGGGGG
GGLKTTSRRT ASLNPIPSSP PSPPPRPPLR SRRKSKSPSS RYNHTAPKQA LDVDKIGGGS
KSEDLRKTRN GSRDLRGHHI SELDRKWEGV ALELQCRGSR MRSAVYQTSD LPSMVKAKKQ
LDQGYSRGQI DRSKLKATFV
//
