ID A0A3B3YF83_9TELE Unreviewed; 626 AA.
AC A0A3B3YF83;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Transcription factor E2-alpha {ECO:0000256|ARBA:ARBA00041064};
DE AltName: Full=Transcription factor 3 {ECO:0000256|ARBA:ARBA00041234};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000026016.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000026016.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3B3YF83; -.
DR Ensembl; ENSPMET00000003640.1; ENSPMEP00000026016.1; ENSPMEG00000009474.1.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd18943; bHLH_E-protein_E47-like; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR11793; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR11793:SF7; TRANSCRIPTION FACTOR E2-ALPHA; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 522..575
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 626 AA; 66524 MW; 5E34027DC2520965 CRC64;
MATVENDKEL SDLLDFSAMF EPPVSNGKNG PTTLASSQFG GPGVDERRGS SPWGPGEQTS
PSFNQGRVFE EGLYSERESL ASTPVFGPGI AGKAERGSYS SFGTQPGFMP SEIPLPSPDS
LSPPSAKSNS QFYSSYERKR PAQDLTANPQ PKKIRKVPPG LPSSVYPTAT GEDFNRDTTC
FPASKAGNVY QPAYYMQDAH PPSDPWGSAG SMIQPGYSAV LGNSPHLGQH GPFTAINPQD
RMKRHPLPLS PQNYPLHGSE VNGAHPTSFH AGSSSFGVPS HTPPIAGTET IMANRGAVPG
SSGDEIGKAL ASIYPSDPNS NAFPPSPSTP SGSPQAVSGS ASQWTRSSGQ ATPSPNFEGG
IQSMQSKLED RLDEAINVLQ RHASGQGGPG LAEMHSLLSA GLGIAPGFNS AALGLASRLQ
GLVSSHLEDS VGLPSSGGVL HHGPASVHLG SQQDGFTGLP GSGNRSGGTA IKREEKEDDE
NCSITDKSED DRKDLKARLR TSLVSLTDEN LTAEEKEQRE RDRRLANNAR ERVRVRDINE
AFRELGRMCQ VHLQSDKAQT KLVILQQAVQ VILSLEKQVR ERNLNPKAAC LKRREEEKVP
GLEHQLQLGG GHPALGGDGH NPVSHM
//
