ID   A0A3B3YFG1_9TELE        Unreviewed;       991 AA.
AC   A0A3B3YFG1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=GTPase activating Rap/RanGAP domain like 3 {ECO:0008006|Google:ProtNLM};
OS   Poecilia mexicana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000026084.1, ECO:0000313|Proteomes:UP000261480};
RN   [1] {ECO:0000313|Ensembl:ENSPMEP00000026084.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B3YFG1; -.
DR   Ensembl; ENSPMET00000003461.1; ENSPMEP00000026084.1; ENSPMEG00000009806.1.
DR   Proteomes; UP000261480; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR001180; CNH_dom.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   PANTHER; PTHR15711:SF62; GTPASE-ACTIVATING RAP_RAN-GAP DOMAIN-LIKE PROTEIN 3; 1.
DR   PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR   Pfam; PF00780; CNH; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SMART; SM00036; CNH; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50219; CNH; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT   DOMAIN          147..363
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   DOMAIN          445..762
FT                   /note="CNH"
FT                   /evidence="ECO:0000259|PROSITE:PS50219"
FT   REGION          769..796
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          896..941
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        769..792
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        907..930
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   991 AA;  110952 MW;  9DD867A8FE479F81 CRC64;
     METKLISSDA DGAIHRAGRF RVENGSLDEA SDYTPGTWRR TDVHLENPEY HTRWYFKYFL
     GKVHQNYVGT DAEKNPFYLS VVLSDQNNQR VPQYRAILWR KTGTLKISLP YSPTKTLSVK
     SILSAMNMDR FEKGPREILN PEIQKDLLVL EEQEGSVNFK FGVLFARDGQ LTDDEMFSNE
     TGSENFDKFL NLLGDTVTLQ GWAGYRGGLD TKNDTTGLQS IYTVYQGHEL MFHVSTMLPY
     SKENKQQVER KRHIGNDIVT IVFQEGDDAS SSFKPSMIRS HFTHIFALVR YNSQNDSYRL
     KIFSEESVPL FGPPLPSPPV FTDHHEFRDF LLVKLINGEK ATLETPTFAQ KRQRTLDMLI
     RSLYQDLMPD LHKNMLNRRS FSDVLPESPK SARKKEEARQ AEFVRIGQAL KLKTIVRGDA
     PTSLVTTGLC RKEPWESQSF CSTFPYEIIC ADSWGQSLLV ATDTAGVLML DGPDPPLPGA
     ETPTLPPVQV FDKTMAVKQM HILEPQDLLI TRADKGKDAR LYVFRLGGIK RGLEERQLVR
     SKCDCRENKL EKTKGCHLYS INTHHGSELR IVAAIRTKLL LITRKHPRFS AVATGADSPV
     EEFQYIREIC LCDPPVVMAL VDGPTGENDN MICVAYKHQF DLINESTGDA YRLHHVDANR
     VNFVAAIDVY EDGEAGLLLC YNYICYYKKV CPFNGSTPMI QSNTSDFQFS WNQMPNAIVC
     AFPYILAFTT DSIEIRLVVN GNLVYTAVVP ELQLAASRSD IYFVSSAPVS SASNCSSRDT
     SSQSSPQTPT GYEMPVFPSP LGDDSIRIPY GTKLSLYMSK DAEGEATCKQ IFKIPLCNLV
     GRSIERPLKS PLVNKVMTAP APAMMASTPL ISATHSLSLS RMEIKEIASR TRKELLGLTE
     EPSGKSDSGS VKQRKMSKKN TDEDPKARAL TSTNSDRLAS DSVDAELDVQ LHCSSALEAD
     PEMVVLQEGS PPLASAFALS TSFEDDVLDL K
//