ID A0A3B3YGA9_9TELE Unreviewed; 742 AA.
AC A0A3B3YGA9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Golgi associated, gamma adaptin ear containing, ARF binding protein 3a {ECO:0008006|Google:ProtNLM};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000026188.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000026188.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004150}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GGA protein family.
CC {ECO:0000256|ARBA:ARBA00008099}.
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DR RefSeq; XP_014846672.1; XM_014991186.1.
DR STRING; 48701.ENSPMEP00000008006; -.
DR Ensembl; ENSPMET00000003181.1; ENSPMEP00000008006.1; ENSPMEG00000009704.1.
DR Ensembl; ENSPMET00000003201.1; ENSPMEP00000026188.1; ENSPMEG00000009704.1.
DR GeneID; 106920274; -.
DR KEGG; pmei:106920274; -.
DR CTD; 492643; -.
DR OrthoDB; 2917368at2759; -.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd14240; GAT_GGA3; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.60.40.1230; -; 1.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR008153; GAE_dom.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR044111; GAT_GGA3.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR027422; GGA1-3.
DR InterPro; IPR041198; GGA_N-GAT.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR45905:SF3; ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA3; 1.
DR PANTHER; PTHR45905; GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF18308; GGA_N-GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50180; GAE; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 15..145
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 170..297
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT DOMAIN 613..734
FT /note="GAE"
FT /evidence="ECO:0000259|PROSITE:PS50180"
FT REGION 305..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 742 AA; 79785 MW; BBB9085F110ABEF3 CRC64;
MADDGESLES WLNKATNPSN RQEDWEYIMG FCDQINKELE GPQISVRLLA HKIQSPQEWE
AMQALTVLEA CMKNCGRRFH NEVGKFKFLN ELIKVVSPKY LGDRVSDKVK MKVIEMLYTW
TVSLPDEAKI CEAYQMLKSQ GIVVVDPEVS LNATLIPSPS PRPKNPVFDD EKKSKRLAEL
LKSKKPEDLQ EANRLIKNMV KEDEVRSQRA AKQKNTLEAV SNSVKLLNEM LAHFSPEDST
EEDKELIKEL YNDCDKLRQT VFKLATETED DDSSLGEILQ ANDDLSSAIN SYKKIVEGQS
ISGDADVAQG TQTPATQGSE GTNKSEILID LVGLDTKSPS QHEPQTSSLV FSGDLLCGST
TTDLQSKTAA PPSAALSLLD EELLSLGLND PGPVVNESST SNQSNHLPPS QDSGQDLALF
DSSLPPAFDA LSAPSLFQQA LSTTPAPATS TRTTTASSAS NFPAFFAPPA ATASDLPPSV
IFPPPLGSAL TAAAPAGPSP SHSVTAPAFS AGRQHVSLPG AFQPAVSSLS HNLQDLAMLD
LGGSDNHSGT STSAMITGMH GWSTPPALRS HPDDSPLLRS LSPIQPMSQA SPSKGDEVSL
AAVFVPLEAI SPSTLCPVTA YDKNGVRVLL HFASDCPPGR PDVLVMVASM LNTAPQPVRN
IVLQAAVPRT MKVKLQPPSG AELAPFNPIL PPAAISQVVL LANPLKEKVR MRYKLMFTLG
EQSFTEVGEV NDFPPADRWG AL
//
