ID A0A3B3YGT6_9TELE Unreviewed; 313 AA.
AC A0A3B3YGT6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=GPN-loop GTPase 2 {ECO:0000256|ARBA:ARBA00014588, ECO:0000256|RuleBase:RU365059};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000026562.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000026562.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Small GTPase required for proper localization of RNA
CC polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly
CC step prior to nuclear import. {ECO:0000256|ARBA:ARBA00003181,
CC ECO:0000256|RuleBase:RU365059}.
CC -!- SUBUNIT: Binds to RNA polymerase II (RNAPII).
CC {ECO:0000256|RuleBase:RU365059}.
CC -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC {ECO:0000256|ARBA:ARBA00005290, ECO:0000256|RuleBase:RU365059}.
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DR RefSeq; XP_014866006.1; XM_015010520.1.
DR AlphaFoldDB; A0A3B3YGT6; -.
DR STRING; 48701.ENSPMEP00000026562; -.
DR Ensembl; ENSPMET00000002303.1; ENSPMEP00000026562.1; ENSPMEG00000010279.1.
DR GeneID; 106932046; -.
DR KEGG; pmei:106932046; -.
DR CTD; 54707; -.
DR OrthoDB; 168004at2759; -.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd17871; GPN2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004130; Gpn.
DR InterPro; IPR030231; Gpn2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR21231:SF3; GPN-LOOP GTPASE 2; 1.
DR PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR Pfam; PF03029; ATP_bind_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|RuleBase:RU365059};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU365059};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365059}.
SQ SEQUENCE 313 AA; 35118 MW; FF3D2227E9D31AEB CRC64;
MSAQPGLKPS LRFGQVVIGP PGSGKTTYCQ GMQEFLTSLG RKVVVVNMDP ANEGIPYSCA
VDVSELVTLD DVMENLKLGP NGGLLYCMEY VEANLDWLES KLTQCSDCYF LFDCPGQVEL
YTHQSSVKNI FSQLAKWNFR LTAVHLVDSH YCADPAKFIS VLCTSLSTML HVELPHVNIL
SKMDLIEQYG KLAFNLDFYT EVMDLTYLLD HLAADPFFKK FRHLNEKLAE VIQDYGLVSF
VPLNVQDKDS MIQVLRAVDK ANGYCFGDLE ERNLQAMMSA AVGADFQFSS TLGVQERYVE
TGEKTVEEEM MEL
//
