ID A0A3B3YM60_9TELE Unreviewed; 843 AA.
AC A0A3B3YM60;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Rap guanine nucleotide exchange factor (GEF) 3 {ECO:0008006|Google:ProtNLM};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000028140.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000028140.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3B3YM60; -.
DR Ensembl; ENSPMET00000017996.1; ENSPMEP00000028140.1; ENSPMEG00000013005.1.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd04437; DEP_Epac; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF24; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 3; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 43..113
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 175..276
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 312..446
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 582..809
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 843 AA; 96049 MW; DF5735C42E5222B8 CRC64;
MNVTPLPEAL DSKDSMKQFL SDRVVKAARS VYSVMVEKNP GLIRDRKHHL KTHRQCCSGK
ELVDWLMKQS ECLQSRSQAA GMWQVLVDEG ILVHVKQDLN FLDKDTQFYR FQDSEFGLNH
VSNEKDLEDE LHEALSLLSQ LGPDALLTMI LRKCPSQRSA EDIEVIYEEL LHVKAAAHLS
SSVRKELAAV LVFESHVKSG TVLFSQGDKG TSWYIIWKGS VNVITHGKGI VTTLHEGEDF
GQLALLNDAP RAATIILRED NCHFLRVDKH DFIRILKDVE ANTVRLEEHG KTVLVLEKSA
DCNGQGGAAA NSKYTVMSGT PEKILEHLLD TLKLDSNGND PIDPCVSDFL LTHKVFMPSS
QLCSALQHHY QAELSKGSDQ EKTAYIFNTK QKVVKLIAQW VALYGLLLKE DPEVGDFLER
LKKEVAADYR LSSILKEQFR ERRRTKVMEN GYQSLSRNQQ FDWFSSCEEP VGRLQPIKAQ
DKVLYEIYKA DSKPLSLMLP VSSSVQEVMS AIVKADGDHV LVKMNSSGER AQLKLDATAV
YTALGLNERL FICTSSEVEQ LRPLKDQQGP EQATTDLIEQ MSSKDIATEL TNYDWELFTA
MHEVELVYYI FGRHKCPGAT TANLERFVRH FNVVQYWVVT ELCLCEDLVK RAILLKKFIK
IASVLKEQRN LNSFFAVMFG LSNSSVQRLY KTWERIPSKT KRIYCAYERL MDPSRNHRAY
RLAVAKLSPP YIPFMPLLLK DMTFIHEGNP NYVDKLVNFE KMRMLAKTVK IVRGCRSQPY
VPSSPQRGLA DRMFLDGPAT RLSTYSDHAF PLRSPSNIRQ YIQNLKVIDN QRKLTQLSRT
IEC
//
