ID   A0A3B3YN65_9TELE        Unreviewed;      1278 AA.
AC   A0A3B3YN65;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Nephrocystin-3 {ECO:0000256|ARBA:ARBA00040387};
OS   Poecilia mexicana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000028801.1, ECO:0000313|Proteomes:UP000261480};
RN   [1] {ECO:0000313|Ensembl:ENSPMEP00000028801.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B3YN65; -.
DR   Ensembl; ENSPMET00000019275.1; ENSPMEP00000028801.1; ENSPMEG00000014219.1.
DR   Proteomes; UP000261480; Unplaced.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR45641:SF1; NEPHROCYSTIN-3; 1.
DR   PANTHER; PTHR45641; TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870); 1.
DR   Pfam; PF13374; TPR_10; 1.
DR   Pfam; PF13424; TPR_12; 3.
DR   Pfam; PF13176; TPR_7; 1.
DR   SMART; SM00028; TPR; 8.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50005; TPR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW   ProRule:PRU00339}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT   REPEAT          938..971
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          1088..1121
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          1130..1163
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          1172..1205
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          1214..1247
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          86..180
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1278 AA;  145306 MW;  A4F94CBF3E6A7DF9 CRC64;
     MGTASSLVSP GEVIEDGYGG EGGEACEIPV EVKPKARLLR SSFRRGPRVI GASFKSTGSV
     DLEYAAEYER LRKEYEIFRV SKNNEITSMQ KKEAKLDEEN KRLRAELQAL QKTYQKILRE
     KEAALETKYQ AMERAATFEH DRDKVKRQFK IFRETKEKEI QDLLRAKRDL EAKLQQLQTQ
     GIHIFSPNDS DSDDNQTTVT AVGTQCEYWS GGVLGSEPSM GSMMQLQQTF RGPEFAHSLI
     DVEGPFANVS RDDWDAAVAS LLQVSPHVPQ ALWSNTVRCY LISTQDTKAE MEIFIKKHSA
     ALRRMCEGLG HFYLNVYFPE ENAASYAMVR RQEIERSSIC VLLLKSTVTS SVVEDCEEAF
     VKNPDGHPLV LYLRTEEDRG LTGPIRHSSA EEGAGLIYAQ LEKVIKQELL GFEGGDDDSK
     DASIDEGREE DLGDVLWDLH DEQEQIESYQ QACSSTTSQL GFQKYIDLLN DMIAAPPPTP
     PLLVSGGPGS GKSLLLSKWI ELQQKQSPNT LFLYHFVGRP LSISSEPVLI IKRLTVKLLQ
     HFWSISGLSM DPSKILEEFP RWLERLSARH QGNIIIIIDS VDQIKQAERH MKWLIDPLPV
     NVRVVVSVNV ETCPQAWRLW PTLHLDPLSA REVKSVVSAE CLTTDFRLTK DQEKKLERHC
     RSASTCNALY VTLLARMITR SVVSTFCLEQ CLQCQDTLSL YRLALKMMLK FLNTDRERHM
     MKEMLCLVFS SHNGVSESEA LDLFPELEWA ALSSLLYHLN RLCIVTLRCG LIRFQHLQAC
     EAVRLEFLGG GSGCASYREK LIHYFSQQLS QDCVTWRVAD ELPWLFQQQE DKAKLQLSLL
     NLFVSQNLYK RGHFSELLAY WQYVGKDKSS MAAEYFDSLK RYEQSCESED SMTKLANLYE
     TLGRFLKDLG LPSQAVAPLQ RSLEIRETAL DPDHPSVARS LHQLAGVYVQ WKKYGNAEQL
     YKQALEISEN AYGAEHVAVA QELESLAMLY QKQNKYEQAE KLRKRSVRIR QKTARQKGQM
     YGFTLLRRRA LQLEELTLGK DSADCAKTLN ELGVLYYLQN NLDAAKVFLT RSLEMRQRVL
     GPDHPDCAQS LNNLAALHTE RREYEAAEDM YERALEIRRK ALSPDHPSLA YTVKHLAMLY
     KRRGKLEKAV PLYELSLEIR EKSFGPKHPS VATALVNLAV LYCQLKKHSE ALPLYERALK
     VYEDSLGRSH PRVGETLKNL AVLSYEEGDF ERAAELYKRA MEIKEAEPSL VCGNAPSHHS
     SSGDTFSLKT PVMNFFLG
//