ID   A0A3B3YNM1_9TELE        Unreviewed;       815 AA.
AC   A0A3B3YNM1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
OS   Poecilia mexicana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000028748.1, ECO:0000313|Proteomes:UP000261480};
RN   [1] {ECO:0000313|Ensembl:ENSPMEP00000028748.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
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DR   AlphaFoldDB; A0A3B3YNM1; -.
DR   Ensembl; ENSPMET00000031575.1; ENSPMEP00000028748.1; ENSPMEG00000014129.1.
DR   Proteomes; UP000261480; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR   GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 5.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR017241; Toll-like_receptor.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24365:SF551; LOW QUALITY PROTEIN: TOLL-LIKE RECEPTOR 13-RELATED; 1.
DR   PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR   Pfam; PF13855; LRR_8; 4.
DR   Pfam; PF01582; TIR; 1.
DR   PIRSF; PIRSF037595; Toll-like_receptor; 4.
DR   SMART; SM00369; LRR_TYP; 14.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS51450; LRR; 4.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW   ECO:0000256|PIRNR:PIRNR037595};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW   ECO:0000256|PIRNR:PIRNR037595};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        614..637
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          664..796
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   815 AA;  94435 MW;  6E152359C0D860CE CRC64;
     LTFFLELNLE TIPDDFPKNA ASVQLNNNRL KKITRKDFSK MSQLRRLHLG FNQIDSVYDR
     SFSDLVFLKT LSMEHNNLNH LTRDMFYGLS NLTLLNLSSN FIQFIHCSAF RHMYRLQTLD
     LGNNDLQQIV EIQPVLQLPQ IQTLKLRCNQ FSSFETKELS LNFSSLREID ISGRNLERFS
     ITTPIFPFLQ MISLSGCEGN STLKWDITDK TLLKRVVKLY IADAVLSFIE TEKVLKSLYS
     LSHLRLQHLD EWIRKGLLTT VCKLPLYLRE SYISKLPKGS LQSLEQLQFL NLSTNRLTNV
     PFDVRHLSSL EILLVGNNLI SELNCEDFLN TTRLMELYLN NNRITKLKRC VLQSLTDLKV
     LGLSNNLILT VGDTFKKTLF KLEVLDMSHN SIISLESGDF QGLQKLKYLN VTRNSIGKVN
     PEVFQELINL ESLTVCLPYD YEPNFTGLQL LEHITFFRAL NIYINAPPAE TFHFNPQLKS
     LTLAETDLSN LKPGMFLPIP NLQTLDLAKC KIKSLDFLTQ ANLSALRYLK LSNNEISQIN
     ESVYQALPSL TYLDLSNNPF TCECLNADFI TWVKSNKETQ VINAHQYVCS FPVQKQGTLL
     LDFDIQSCWD QGNFFFFVSS SSLVVLTLLT SFVYHFLKWH LIYMFHLFLA FLYDSRKGKK
     ADSYQFDAFV SYNSQDEDWV YHEMLPVLEE EQGWRLCKPI IENITDAIYG SRKTICVISR
     SYLQSEWCSR EIQMASFRLF DEKKDVLILL FLEDIPPQHL SPYHRMRKLL KKCTYLSWSK
     AEKHPGVFWQ NVRKALQTKD DPPKDPALLT GPTQC
//