ID A0A3B3YPZ7_9TELE Unreviewed; 377 AA.
AC A0A3B3YPZ7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Enoyl reductase (ER) domain-containing protein {ECO:0000259|SMART:SM00829};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000029424.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000029424.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR RefSeq; XP_014829225.1; XM_014973739.1.
DR AlphaFoldDB; A0A3B3YPZ7; -.
DR STRING; 48701.ENSPMEP00000029424; -.
DR Ensembl; ENSPMET00000020469.1; ENSPMEP00000029424.1; ENSPMEG00000015151.1.
DR GeneID; 106907858; -.
DR KEGG; pmei:106907858; -.
DR OrthoDB; 1077476at2759; -.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006066; P:alcohol metabolic process; IEA:UniProt.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43880; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43880:SF3; ALCOHOL DEHYDROGENASE 8A-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 17..373
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 377 AA; 40618 MW; 54C5969BE11708A0 CRC64;
MATAGKVIRC KAAVAWEPNK PLVIEEIEVA PPQANEVRIK IVATGVCHTD LYHLFEGMHK
DGFPVVLGHE GAGIVESVGP GVTEFQPGDK VIPLFISQCR ECRFCKSPKT NQCVKGWAAD
RYDVMALEET RLSCKGKKLL QFLGTSTFSE YTVLNQIAVA KIDPAAPLDK VCLLGCGVCT
GFGAAVNTAK VEAGSTCAVF GLGAVGLAAV MGCKFAGAKR IIAVDINPEK FEKAKVFGAT
EFVNPKDHSR PINQVLAEMT DGGVDYSLEC VGNVAVMRSA LESCVKGWGV SVLVGWTDLH
DFAARPIQLI AGRTWKGTLF GGFKSKDGVP EMVKAYLDRK VKLDEFITHS MTLEKVNEAV
ELMKHGQCIR TVLRVSP
//
