ID A0A3B3YQ48_9TELE Unreviewed; 937 AA.
AC A0A3B3YQ48;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Complement component 6 {ECO:0008006|Google:ProtNLM};
OS Poecilia mexicana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48701 {ECO:0000313|Ensembl:ENSPMEP00000029482.1, ECO:0000313|Proteomes:UP000261480};
RN [1] {ECO:0000313|Ensembl:ENSPMEP00000029482.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR RefSeq; XP_014857357.1; XM_015001871.1.
DR AlphaFoldDB; A0A3B3YQ48; -.
DR STRING; 48701.ENSPMEP00000029482; -.
DR Ensembl; ENSPMET00000020591.1; ENSPMEP00000029482.1; ENSPMEG00000015289.1.
DR GeneID; 106926770; -.
DR KEGG; pmei:106926770; -.
DR CTD; 729; -.
DR OrthoDB; 5303272at2759; -.
DR Proteomes; UP000261480; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 2.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 3.30.60.30; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 3.
DR InterPro; IPR048828; C6_KAZAL.
DR InterPro; IPR048831; C8A_B_C6_EGF-like.
DR InterPro; IPR003884; FacI_MAC.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR PANTHER; PTHR45742:SF4; COMPLEMENT COMPONENT C6; 1.
DR Pfam; PF21288; C6_KAZAL; 1.
DR Pfam; PF21195; C8A_B_C6_EGF-like; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF01823; MACPF; 1.
DR Pfam; PF00084; Sushi; 2.
DR Pfam; PF00090; TSP_1; 3.
DR PRINTS; PR00764; COMPLEMENTC9.
DR SMART; SM00032; CCP; 2.
DR SMART; SM00057; FIMAC; 2.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00457; MACPF; 1.
DR SMART; SM00209; TSP1; 3.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 3.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50923; SUSHI; 2.
DR PROSITE; PS50092; TSP1; 3.
PE 3: Inferred from homology;
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Membrane attack complex {ECO:0000256|ARBA:ARBA00023058};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..937
FT /note="Complement component 6"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017393924"
FT DOMAIN 179..524
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 643..702
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 703..766
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 149..167
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 161..176
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 673..700
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 705..748
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 937 AA; 105492 MW; 81547C023E898CCA CRC64;
MSPSRSMMLP LQLLLLGFMS GSLACHCDRY PWSPWSACTR TCNYGTQSRS RNVQYDDYYW
KNSCHQMCSR YDTRGCNQQA CPINCVLSEF SRWSDCSPCA RKQFRTRSVV RPSQFGGSEC
SVELTEERPC HPSKDCQLPA VGCRGDFKCD NGRCINSTLT CNKQNDCGDN SDERGCGAPT
VVCPSERRPA PGADLVGNGF DFLAEEPRGA VLDNMFMGGS CIIRRPQSTL LYHRVPHNFK
TFDIKVGVLE DFSIDPQPVV SEPVVIKKSG QSEQNTRDQD SFHFLFFYGR RSSSSSLTSS
KEAFEASKKK DSKFFRVHQL LPISNFTVKD PQDLVLSLPF LQFLHALPLD YNYALYREIF
QRFGTHYYSS GKLGGLYDLL YQYSREEIKS SGETEETING CLSRDTSWTI ILYSESSSVT
RCTNNRMTEK YQGSFIQASE KSFSMVKGGG AREAGALAWE RQGAAPDKTS YKNWAKSVID
NPALVDYQLR PIIDLVRGIP CAVTKRRHLR KALLQYLEEF DTCKCAPCPN NARPVLSGTE
CKCVCQTGTF GTNCEIRAPD YTSEVVDGYW SCWGPWSSCS ASMRRHRTRK CDNPAPLRGG
QPCDGPNRQE EPCPLSLFEK KESCDNDDEF TVGWRDELPP GVEGCLRPQR PSHSFLRKSK
QYYSFGEDEE FQCFTGFELE GFQFINCQPD GTWSQPRGRC IRRLCVAPEV PENMELYPPK
ATYRVGESVG FNCNETGLMP MPRGIYRCSR KLTWEPPLPA DLRCTDEEPF VPDGQCGPGQ
KRQRSGCVCV ERESCLSQSA SLCVLNTNLD VAVSMSLCSF HAGRCHGDPL FYIGEGVCDS
VEPTKLEWAR FRAKMSPRSS LHVPCDLDSC YDWETCSASK KCQCKAALDC PRTSDQMFCV
KLKPMQMIRS MSLCTLAAIT CSGREHEILN EGVCQSR
//
